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10.4049/jimmunol.1302617 http://scihub22266oqcxt.onion/10.4049/jimmunol.1302617 C3991608!3991608!24610013     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2014 ; 192 (7): 3166-79 Nephropedia Template TP {{tp|p=24610013|t=2014. B cells in T Follicular Helper Cell Development and Function: Separable Roles in Delivery of ICOS Ligand and Antigen |pdf=|usr=}}{{24610013}} gab.com Text B cells in T Follicular Helper Cell Development and Function: Separable Roles in Delivery of ICOS Ligand and Antigen JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24610013 #FOAvip B cells are required for follicular helper T (Tfh) cell development, as is the ligand for ICOS (ICOS-L); however, the separable contributions of Ag and ICOS-L delivery by cognate B cells to Tfh-cell development and function are unknown. We find that Tfh-cell and germinal center differentiation are dependent upon cognate B-cell display of ICOS-L, but only when Ag presentation by the latter is limiting, with the requirement for B-cell expression of ICOS-L overcome by robust Ag delivery. These findings demonstrate that Ag-specific B cells provide different, yet compensatory signals for Tfh-cell differentiation, while reconciling conflicting data indicating a requirement for ICOS-L expression on cognate B cells for Tfh-cell development with those demonstrating this requirement could be bypassed in lieu of that tendered by non-cognate B cells. Our findings clarify the separable roles of delivery of Ag and ICOS-L by cognate B cells for Tfh-cell maturation and function, and have implications for using therapeutic ICOS blockade in settings of abundantly available Ag, such as in systemic autoimmunity. Twit Text FOAVip B cells in T Follicular Helper Cell Development and Function: Separable Roles in Delivery of ICOS Ligand and Antigen ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24610013 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24610013 #FOAvip English Wikipedia <ref>{{Cite pmid|24610013}}</ref> B cells in T Follicular Helper Cell Development and Function: Separable Roles in Delivery of ICOS Ligand and Antigen #MMPMID24610013 Weinstein JS; Bertino SA; Hernandez SG; Poholek AC; Teplitzky TB; Nowyhed HN; Craft J J Immunol 2014[Apr]; 192 (7): 3166-79 PMID24610013show ga B cells are required for follicular helper T (Tfh) cell development, as is the ligand for ICOS (ICOS-L); however, the separable contributions of Ag and ICOS-L delivery by cognate B cells to Tfh-cell development and function are unknown. We find that Tfh-cell and germinal center differentiation are dependent upon cognate B-cell display of ICOS-L, but only when Ag presentation by the latter is limiting, with the requirement for B-cell expression of ICOS-L overcome by robust Ag delivery. These findings demonstrate that Ag-specific B cells provide different, yet compensatory signals for Tfh-cell differentiation, while reconciling conflicting data indicating a requirement for ICOS-L expression on cognate B cells for Tfh-cell development with those demonstrating this requirement could be bypassed in lieu of that tendered by non-cognate B cells. Our findings clarify the separable roles of delivery of Ag and ICOS-L by cognate B cells for Tfh-cell maturation and function, and have implications for using therapeutic ICOS blockade in settings of abundantly available Ag, such as in systemic autoimmunity. äB cells in T Follicular Helper Cell Development and Function: Separabl(epmc).pdf DeepDyve Pubget Overpricing