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10.1182/blood-2013-08-355818 http://scihub22266oqcxt.onion/10.1182/blood-2013-08-355818 C3990910!3990910!24608975     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Blood 2014 ; 123 (16): 2451-9 Nephropedia Template TP {{tp|p=24608975|t=2014. Notch signaling: switching an oncogene to a tumor suppressor |pdf=|usr=}}{{24608975}} gab.com Text Notch signaling: switching an oncogene to a tumor suppressor JO: Blood http://www.kidney.de/pget.php?&tw=1&pmid=24608975 #FOAvip The Notch signaling pathway is a regulator of self-renewal and differentiation in several tissues and cell types. Notch is a binary cell-fate determinant, and its hyperactivation has been implicated as oncogenic in several cancers including breast cancer and T-cell acute lymphoblastic leukemia (T-ALL). Recently, several studies also unraveled tumor-suppressor roles for Notch signaling in different tissues, including tissues where it was before recognized as an oncogene in specific lineages. Whereas involvement of Notch as an oncogene in several lymphoid malignancies (T-ALL, B-chronic lymphocytic leukemia, splenic marginal zone lymphoma) is well characterized, there is growing evidence involving Notch signaling as a tumor suppressor in myeloid malignancies. It therefore appears that Notch signaling pathway?s oncogenic or tumor-suppressor abilities are highly context dependent. In this review, we summarize and discuss latest advances in the understanding of this dual role in hematopoiesis and the possible consequences for the treatment of hematologic malignancies. Twit Text FOAVip Notch signaling: switching an oncogene to a tumor suppressor ????Blood http://www.kidney.de/pget.php?&tw=1&pmid=24608975 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24608975 #FOAvip English Wikipedia <ref>{{Cite pmid|24608975}}</ref> Notch signaling: switching an oncogene to a tumor suppressor #MMPMID24608975 Lobry C; Oh P; Mansour MR; Look AT; Aifantis I Blood 2014[Apr]; 123 (16): 2451-9 PMID24608975show ga The Notch signaling pathway is a regulator of self-renewal and differentiation in several tissues and cell types. Notch is a binary cell-fate determinant, and its hyperactivation has been implicated as oncogenic in several cancers including breast cancer and T-cell acute lymphoblastic leukemia (T-ALL). Recently, several studies also unraveled tumor-suppressor roles for Notch signaling in different tissues, including tissues where it was before recognized as an oncogene in specific lineages. Whereas involvement of Notch as an oncogene in several lymphoid malignancies (T-ALL, B-chronic lymphocytic leukemia, splenic marginal zone lymphoma) is well characterized, there is growing evidence involving Notch signaling as a tumor suppressor in myeloid malignancies. It therefore appears that Notch signaling pathway?s oncogenic or tumor-suppressor abilities are highly context dependent. In this review, we summarize and discuss latest advances in the understanding of this dual role in hematopoiesis and the possible consequences for the treatment of hematologic malignancies. äNotch signaling: switching an oncogene to a tumor suppressor (epmc).pdf DeepDyve Pubget Overpricing