Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

http://scihub22266oqcxt.onion/ C3990870!3990870!24739520     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Exp+Rheumatol 2014 ; 32 (2): 251-5 Nephropedia Template TP {{tp|p=24739520|t=2014. Alum, an Aluminum Based Adjuvant, Induces Sjögren?s Syndrome-like Disorder in Mice |pdf=|usr=}}{{24739520}} gab.com Text Alum, an Aluminum Based Adjuvant, Induces Sjögren s Syndrome-like Disorder in Mice JO: Clin Exp Rheumatol http://www.kidney.de/pget.php?&tw=1&pmid=24739520 #FOAvip Objective: Adjuvant induced innate immune responses have been suspected to play a role in the initiation of certain autoimmune disorders. This study investigates the role of alum, an aluminum based adjuvant in the induction of Sjögren?s syndrome-like disorder in mice. Methods: Inbred, female New Zealand Mixed (NZM) 2758 strain of mice were injected with alum. Control mice were treated similarly with PBS. Mice were monitored for salivary gland dysfunction by measuring pilocarpine induced salivation. Presence of lymphocytic infiltrates within the submandibular glands was studied by histopathology. Autoantibodies to Ro and La proteins were analyzed by ELISA and the presence of anti-nuclear antibodies (ANA) was analyzed by indirect immunofluorescence. Results: By eight weeks after treatment, the saliva production in alum treated mice was significantly decreased in comparison to the PBS treated mice. This functional loss persisted till the termination of experiments at 20wks. The incidence and severity of sialoadenitis was significantly higher in the alum treated mice. Although there were no differences in the levels of anti-Ro/La autoantibodies in sera of alum and PBS treated groups, the alum group showed higher ANA reactivity. Conclusion: In the NZM2758 mice, alum induces a Sjögren?s syndrome-like disorder that is characterized by chronic salivary gland dysfunction and the presence of lymphocytic infiltrates within the salivary glands. Thus, the potential of aluminum based adjuvants for induction of autoimmunity should be closely monitored in individuals genetically susceptible to developing autoimmune disorders. Twit Text FOAVip Alum, an Aluminum Based Adjuvant, Induces Sjögren s Syndrome-like Disorder in Mice ????Clin Exp Rheumatol http://www.kidney.de/pget.php?&tw=1&pmid=24739520 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24739520 #FOAvip English Wikipedia <ref>{{Cite pmid|24739520}}</ref> Alum, an Aluminum Based Adjuvant, Induces Sjögren?s Syndrome-like Disorder in Mice #MMPMID24739520 Bagavant H; Nandula SR; Kaplonek P; Rybakowska PD; Deshmukh US Clin Exp Rheumatol 2014[Mar]; 32 (2): 251-5 PMID24739520show ga Objective: Adjuvant induced innate immune responses have been suspected to play a role in the initiation of certain autoimmune disorders. This study investigates the role of alum, an aluminum based adjuvant in the induction of Sjögren?s syndrome-like disorder in mice. Methods: Inbred, female New Zealand Mixed (NZM) 2758 strain of mice were injected with alum. Control mice were treated similarly with PBS. Mice were monitored for salivary gland dysfunction by measuring pilocarpine induced salivation. Presence of lymphocytic infiltrates within the submandibular glands was studied by histopathology. Autoantibodies to Ro and La proteins were analyzed by ELISA and the presence of anti-nuclear antibodies (ANA) was analyzed by indirect immunofluorescence. Results: By eight weeks after treatment, the saliva production in alum treated mice was significantly decreased in comparison to the PBS treated mice. This functional loss persisted till the termination of experiments at 20wks. The incidence and severity of sialoadenitis was significantly higher in the alum treated mice. Although there were no differences in the levels of anti-Ro/La autoantibodies in sera of alum and PBS treated groups, the alum group showed higher ANA reactivity. Conclusion: In the NZM2758 mice, alum induces a Sjögren?s syndrome-like disorder that is characterized by chronic salivary gland dysfunction and the presence of lymphocytic infiltrates within the salivary glands. Thus, the potential of aluminum based adjuvants for induction of autoimmunity should be closely monitored in individuals genetically susceptible to developing autoimmune disorders. äAlum, an Aluminum Based Adjuvant, Induces Sjögren?s Syndrome-like Diso(epmc).pdf DeepDyve Pubget Overpricing