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2014 ; 29
(2
): 202-9
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Potential Chemoprevention of 7,12-Dimethylbenz a anthracene Induced Renal
Carcinogenesis by Moringa oleifera Pods and Its Isolated Saponin
#MMPMID24757303
Sharma V
; Paliwal R
Indian J Clin Biochem
2014[Apr]; 29
(2
): 202-9
PMID24757303
show ga
Present investigation shows that hydroethanolic extract of Moringa oleifera
(MOHE) and its isolated saponin (SM) attenuates DMBA induced renal carcinogenesis
in mice. Isolation of SM was achieved by TLC and HPLC and characterization was
done using IR and (1)H NMR. Animals were pre-treated with MOHE (200 and 400 mg/kg
body weight; p.o), BHA as a standard (0.5 and 1 %) and SM (50 mg/kg body weight)
for 21 days prior to the administration of single dose of DMBA (15 mg/kg body
weight). Administration of DMBA significantly (p < 0.001) enhanced level of
xenobiotic enzymes. It enhanced renal malondialdehyde, with reduction in renal
glutathione content, antioxidant enzymes and glutathione-S-transferase. The
status of renal aspartate transaminase, alanine transaminase, alkaline
phosphatase and total protein content were also found to be decreased along with
increase in total cholesterol in DMBA administered mice. Pretreatment with MOHE
and SM significantly reversed the DMBA induced alterations in the tissue and
effectively suppressed renal oxidative stress and toxicity.
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