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10.1002/embr.201338373 http://scihub22266oqcxt.onion/10.1002/embr.201338373 C3989668!3989668!24652853     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+Rep 2014 ; 15 (4): 365-82 Nephropedia Template TP {{tp|p=24652853|t=2014. Regulation of stem cell function by protein ubiquitylation |pdf=|usr=}}{{24652853}} gab.com Text Regulation of stem cell function by protein ubiquitylation JO: EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=24652853 #FOAvip Tissue homeostasis depends largely on the ability to replenish impaired or aged cells. Thus, tissue-resident stem cells need to provide functional progeny throughout the lifetime of an organism. Significant work in the past years has characterized how stem cells integrate signals from their environment to shape regulatory transcriptional networks and chromatin-regulating factors that control stem cell differentiation or maintenance. There is increasing interest in how post-translational modifications, and specifically ubiquitylation, control these crucial decisions. Ubiquitylation modulates the stability and function of important factors that regulate key processes in stem cell behavior. In this review, we analyze the role of ubiquitylation in embryonic stem cells and different adult multipotent stem cell systems and discuss the underlying mechanisms that control the balance between quiescence, self-renewal, and differentiation. We also discuss deregulated processes of ubiquitin-mediated protein degradation that lead to the development of tumor-initiating cells. Twit Text FOAVip Regulation of stem cell function by protein ubiquitylation ????EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=24652853 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24652853 #FOAvip English Wikipedia <ref>{{Cite pmid|24652853}}</ref> Regulation of stem cell function by protein ubiquitylation #MMPMID24652853 Strikoudis A; Guillamot M; Aifantis I EMBO Rep 2014[Apr]; 15 (4): 365-82 PMID24652853show ga Tissue homeostasis depends largely on the ability to replenish impaired or aged cells. Thus, tissue-resident stem cells need to provide functional progeny throughout the lifetime of an organism. Significant work in the past years has characterized how stem cells integrate signals from their environment to shape regulatory transcriptional networks and chromatin-regulating factors that control stem cell differentiation or maintenance. There is increasing interest in how post-translational modifications, and specifically ubiquitylation, control these crucial decisions. Ubiquitylation modulates the stability and function of important factors that regulate key processes in stem cell behavior. In this review, we analyze the role of ubiquitylation in embryonic stem cells and different adult multipotent stem cell systems and discuss the underlying mechanisms that control the balance between quiescence, self-renewal, and differentiation. We also discuss deregulated processes of ubiquitin-mediated protein degradation that lead to the development of tumor-initiating cells. äRegulation of stem cell function by protein ubiquitylation (epmc).pdf DeepDyve Pubget Overpricing