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10.1158/1078-0432.CCR-12-3603 http://scihub22266oqcxt.onion/10.1158/1078-0432.CCR-12-3603 C3989546!3989546!24737791     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Cancer+Res 2014 ; 20 (8): 2044-50 Nephropedia Template TP {{tp|p=24737791|t=2014. Molecular Pathways: Interleukin-15 Signaling in Health and in Cancer |pdf=|usr=}}{{24737791}} gab.com Text Molecular Pathways: Interleukin-15 Signaling in Health and in Cancer JO: Clin Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=24737791 #FOAvip Interleukin-15 (IL-15) is a pro-inflammatory cytokine involved in the development, survival, proliferation and activation of multiple lymphocyte lineages utilizing a variety of signaling pathways. IL-15 utilizes three distinct receptor chains in at least two different combinations to signal and exert its effects on the immune system. The binding of IL-15 to its receptor complex activates an ?immune-enhancing? signaling cascade in natural killer cells and subsets of T cells, as well as the induction of a number of proto-oncogenes. Additional studies have explored the role of IL-15 in the development and progression of cancer, notably leukemia of large granular lymphocytes, cutaneous T-cell lymphoma and multiple myeloma. This review provides an overview of the molecular events in the IL-15 signaling pathway and the aberrancies in its regulation that are associated with chronic inflammation and cancer. We briefly explore the potential therapeutic opportunities that have arisen as a result of these studies to further the treatment of cancer. These involve both targeting the disruption of IL-15 signaling as well as IL-15-mediated enhancement of innate and antigen specific immunity. Twit Text FOAVip Molecular Pathways: Interleukin-15 Signaling in Health and in Cancer ????Clin Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=24737791 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24737791 #FOAvip English Wikipedia <ref>{{Cite pmid|24737791}}</ref> Molecular Pathways: Interleukin-15 Signaling in Health and in Cancer #MMPMID24737791 Mishra A; Sullivan L; Caligiuri MA Clin Cancer Res 2014[Apr]; 20 (8): 2044-50 PMID24737791show ga Interleukin-15 (IL-15) is a pro-inflammatory cytokine involved in the development, survival, proliferation and activation of multiple lymphocyte lineages utilizing a variety of signaling pathways. IL-15 utilizes three distinct receptor chains in at least two different combinations to signal and exert its effects on the immune system. The binding of IL-15 to its receptor complex activates an ?immune-enhancing? signaling cascade in natural killer cells and subsets of T cells, as well as the induction of a number of proto-oncogenes. Additional studies have explored the role of IL-15 in the development and progression of cancer, notably leukemia of large granular lymphocytes, cutaneous T-cell lymphoma and multiple myeloma. This review provides an overview of the molecular events in the IL-15 signaling pathway and the aberrancies in its regulation that are associated with chronic inflammation and cancer. We briefly explore the potential therapeutic opportunities that have arisen as a result of these studies to further the treatment of cancer. These involve both targeting the disruption of IL-15 signaling as well as IL-15-mediated enhancement of innate and antigen specific immunity. äMolecular Pathways: Interleukin-15 Signaling in Health and in Cancer (epmc).pdf DeepDyve Pubget Overpricing