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10.1016/j.drudis.2013.10.008 http://scihub22266oqcxt.onion/10.1016/j.drudis.2013.10.008 C3989473!3989473!24140288     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Drug+Discov+Today 2014 ; 19 (4): 450-7 Nephropedia Template TP {{tp|p=24140288|t=2014. Glutaminase regulation in cancer cells: a druggable chain of events |pdf=|usr=}}{{24140288}} gab.com Text Glutaminase regulation in cancer cells: a druggable chain of events JO: Drug Discov Today http://www.kidney.de/pget.php?&tw=1&pmid=24140288 #FOAvip Metabolism is the process by which cells convert relatively simple extracellular nutrients into energy and building blocks necessary for their growth and survival. In cancer cells, metabolism is dramatically altered compared with normal cells. These alterations are known as the Warburg effect. One consequence of these changes is cellular addiction to glutamine. Because of this, in recent years the enzyme glutaminase has become a key target for small molecule therapeutic intervention. Like many oncotargets, however, glutaminase has a number of upstream partners that might offer additional druggable targets. This review summarizes the work from the current decade surrounding glutaminase and its regulation, and suggests strategies for therapeutic intervention in relevant cases. Twit Text FOAVip Glutaminase regulation in cancer cells: a druggable chain of events ????Drug Discov Today http://www.kidney.de/pget.php?&tw=1&pmid=24140288 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24140288 #FOAvip English Wikipedia <ref>{{Cite pmid|24140288}}</ref> Glutaminase regulation in cancer cells: a druggable chain of events #MMPMID24140288 Katt WP; Cerione RA Drug Discov Today 2014[Apr]; 19 (4): 450-7 PMID24140288show ga Metabolism is the process by which cells convert relatively simple extracellular nutrients into energy and building blocks necessary for their growth and survival. In cancer cells, metabolism is dramatically altered compared with normal cells. These alterations are known as the Warburg effect. One consequence of these changes is cellular addiction to glutamine. Because of this, in recent years the enzyme glutaminase has become a key target for small molecule therapeutic intervention. Like many oncotargets, however, glutaminase has a number of upstream partners that might offer additional druggable targets. This review summarizes the work from the current decade surrounding glutaminase and its regulation, and suggests strategies for therapeutic intervention in relevant cases. äGlutaminase regulation in cancer cells: a druggable chain of events (epmc).pdf DeepDyve Pubget Overpricing