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10.1158/1541-7786.MCR-13-0614 http://scihub22266oqcxt.onion/10.1158/1541-7786.MCR-13-0614 C3989371!3989371!24478461     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cancer+Res 2014 ; 12 (4): 485-90 Nephropedia Template TP {{tp|p=24478461|t=2014. Mutational Landscape of the Essential Autophagy Gene BECN1 in Human Cancers |pdf=|usr=}}{{24478461}} gab.com Text Mutational Landscape of the Essential Autophagy Gene BECN1 in Human Cancers JO: Mol Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=24478461 #FOAvip Evidence suggests that the catabolic process of macroautophagy (autophagy hereafter) can either suppress or promote cancer. The essential autophagy gene ATG6/BECN1 encoding the Beclinl protein has been implicated as a haploinsufficient tumor suppressor in breast, ovarian and prostate cancers. The proximity of BECN1 to the known breast and ovarian tumor suppressor breast cancer 1, early onset, BRCA1, on chromosome 17q21, has made this determination equivocal. Here the mutational status of BECN1 was assessed in human tumor sequencing data from The Cancer Genome Atlas (TCGA) and other databases. Large deletions encompassing both BRCA1 and BECN1, and deletions of only BRCA1 but not BECN1, were found in breast and ovarian cancers, consistent with BRCA1 loss being a primary driver mutation in these cancers. Furthermore, there was no evidence for BECN1 mutation or loss in any other cancer, casting doubt on whether BECN1 is a tumor suppressor in most human cancers. Twit Text FOAVip Mutational Landscape of the Essential Autophagy Gene BECN1 in Human Cancers ????Mol Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=24478461 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24478461 #FOAvip English Wikipedia <ref>{{Cite pmid|24478461}}</ref> Mutational Landscape of the Essential Autophagy Gene BECN1 in Human Cancers #MMPMID24478461 Laddha SV; Ganesan S; Chan CS; White E Mol Cancer Res 2014[Apr]; 12 (4): 485-90 PMID24478461show ga Evidence suggests that the catabolic process of macroautophagy (autophagy hereafter) can either suppress or promote cancer. The essential autophagy gene ATG6/BECN1 encoding the Beclinl protein has been implicated as a haploinsufficient tumor suppressor in breast, ovarian and prostate cancers. The proximity of BECN1 to the known breast and ovarian tumor suppressor breast cancer 1, early onset, BRCA1, on chromosome 17q21, has made this determination equivocal. Here the mutational status of BECN1 was assessed in human tumor sequencing data from The Cancer Genome Atlas (TCGA) and other databases. Large deletions encompassing both BRCA1 and BECN1, and deletions of only BRCA1 but not BECN1, were found in breast and ovarian cancers, consistent with BRCA1 loss being a primary driver mutation in these cancers. Furthermore, there was no evidence for BECN1 mutation or loss in any other cancer, casting doubt on whether BECN1 is a tumor suppressor in most human cancers. äMutational Landscape of the Essential Autophagy Gene BECN1 in Human Ca(epmc).pdf DeepDyve Pubget Overpricing