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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Microcirculation
2014 ; 21
(3
): 219-29
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Mechanisms of the inward remodeling process in resistance vessels: is the actin
cytoskeleton involved?
#MMPMID24635509
Castorena-Gonzalez JA
; Staiculescu MC
; Foote C
; Martinez-Lemus LA
Microcirculation
2014[Apr]; 21
(3
): 219-29
PMID24635509
show ga
The resistance arteries and arterioles are the vascular components of the
circulatory system where the greatest drop in blood pressure takes place.
Consequently, these vessels play a preponderant role in the regulation of blood
flow and the modulation of blood pressure. For this reason, the inward remodeling
process of the resistance vasculature, as it occurs in hypertension, has profound
consequences on the incidence of life-threatening cardiovascular events. In this
manuscript, we review some of the most prominent characteristics of inwardly
remodeled resistance arteries including their changes in vascular passive
diameter, wall thickness, and elastic properties. Then, we explore the known
contribution of the different components of the vascular wall to the
characteristics of inwardly remodeled vessels, and pay particular attention to
the role the vascular smooth muscle actin cytoskeleton may play on the initial
stages of the remodeling process. We end by proposing potential ways by which
many of the factors and mechanisms known to participate in the inward remodeling
process may be associated with cytoskeletal modifications and participate in
reducing the passive diameter of resistance vessels.