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2014 ; 11
(ä): 57
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Kinetics of pulmonary immune cells, antibody responses and their correlations
with the viral clearance of influenza A fatal infection in mice
#MMPMID24666970
Lv J
; Hua Y
; Wang D
; Liu A
; An J
; Li A
; Wang Y
; Wang X
; Jia N
; Jiang Q
Virol J
2014[Mar]; 11
(ä): 57
PMID24666970
show ga
Fatal influenza A virus infection is a major threat to public health throughout
the world. Lung macrophages and neutrophils have critical roles for both the
pathogenesis and viral clearance of fatal viral infections. These are complicated
by the interaction of innate immunity and adaptive immunity against viral
infection. In this study, we investigated the overall kinetics of lung
macrophages, neutrophils, CD4?T cells, CD8?T cells, CD38? cells, and CD138?
cells, the levels of antibody and cytokine responses, both in the early and late
phases of fatal infection with A/PR/8/34 (H1N1) virus in mice. The changes in
lung viral load were also evaluated. We found that pulmonary macrophages and
neutrophils both accumulated in the early and late phases of fatal infections and
they positively correlated with the lung and serum antibody titers, and
negatively correlated with the viral load locally. The secretion of IL-6 might
relate to high numbers of macrophages and neutrophils in the early infection. The
work implies that pulmonary macrophages, neutrophils and the antibody response
all have an essential role in virus elimination of fatal influenza A viral
infection. These findings may have implications for the development of
prophylactic and therapeutic strategies in fatal influenza A viral infection.
Further evaluation of the cooperation among macrophages, neutrophils and antibody
responses in eliminating the virus with fatal infection is needed.
|Animals
[MESH]
|Antibodies, Viral/*blood
[MESH]
|Cytokines/blood
[MESH]
|Disease Models, Animal
[MESH]
|Female
[MESH]
|Influenza A Virus, H1N1 Subtype/*immunology
[MESH]