Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.4049/jimmunol.1303205 http://scihub22266oqcxt.onion/10.4049/jimmunol.1303205 C3982198!3982198!24634495     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2014 ; 192 (8): 3925-35 Nephropedia Template TP {{tp|p=24634495|t=2014. B cell differentiation is associated with reprogramming the CTCF-dependent chromatin architecture of the murine MHC-II locus1 |pdf=|usr=}}{{24634495}} gab.com Text B cell differentiation is associated with reprogramming the CTCF-dependent chromatin architecture of the murine MHC-II locus1 JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24634495 #FOAvip The transcriptional insulator CCCTC binding factor (CTCF)2 was shown previously to be critical for human MHC class II gene expression. Whether the mechanisms used by CTCF in humans was similar to that of the mouse and whether the three-dimensional chromatin architecture created was specific to B cells was not defined. Genome-wide CTCF occupancy was defined for murine B cells and LPS-derived plasmablasts by ChIP-seq. Fifteen CTCF sites within the murine MHC-II locus were associated with high CTCF binding in B cells. Only one third of these sites displayed significant CTCF occupancy in plasmablasts. CTCF was required for maximal MHC-II gene expression in mouse B cells. In B cells, a subset of the CTCF regions interacted with each other, creating a three-dimensional architecture for the locus. Additional interactions occurred between MHC-II promoters and the CTCF sites. In contrast, a novel configuration occurred in plasma cells, which do not express MHC-II genes. Ectopic CIITA expression in plasma cells to induce MHC-II expression resulted in high levels of MHC-II proteins, but did not alter the plasma cell architecture completely. These data suggest that reorganizing the three-dimensional chromatin architecture is an epigenetic mechanism that accompanies the silencing of MHC class II genes as part of the cell fate commitment of plasma cells. Twit Text FOAVip B cell differentiation is associated with reprogramming the CTCF-dependent chromatin architecture of the murine MHC-II locus1 ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24634495 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24634495 #FOAvip English Wikipedia <ref>{{Cite pmid|24634495}}</ref> B cell differentiation is associated with reprogramming the CTCF-dependent chromatin architecture of the murine MHC-II locus1 #MMPMID24634495 Majumder P; Scharer CD; Choi NM; Boss JM J Immunol 2014[Apr]; 192 (8): 3925-35 PMID24634495show ga The transcriptional insulator CCCTC binding factor (CTCF)2 was shown previously to be critical for human MHC class II gene expression. Whether the mechanisms used by CTCF in humans was similar to that of the mouse and whether the three-dimensional chromatin architecture created was specific to B cells was not defined. Genome-wide CTCF occupancy was defined for murine B cells and LPS-derived plasmablasts by ChIP-seq. Fifteen CTCF sites within the murine MHC-II locus were associated with high CTCF binding in B cells. Only one third of these sites displayed significant CTCF occupancy in plasmablasts. CTCF was required for maximal MHC-II gene expression in mouse B cells. In B cells, a subset of the CTCF regions interacted with each other, creating a three-dimensional architecture for the locus. Additional interactions occurred between MHC-II promoters and the CTCF sites. In contrast, a novel configuration occurred in plasma cells, which do not express MHC-II genes. Ectopic CIITA expression in plasma cells to induce MHC-II expression resulted in high levels of MHC-II proteins, but did not alter the plasma cell architecture completely. These data suggest that reorganizing the three-dimensional chromatin architecture is an epigenetic mechanism that accompanies the silencing of MHC class II genes as part of the cell fate commitment of plasma cells. äB cell differentiation is associated with reprogramming the CTCF-depen(epmc).pdf DeepDyve Pubget Overpricing