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10.1007/s00018-013-1483-1 http://scihub22266oqcxt.onion/10.1007/s00018-013-1483-1 C3981964!3981964 !24104765     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24104765 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Mol+Life+Sci 2014 ; 71 (11 ): 2165-78 Nephropedia Template TP {{tp|p=24104765 |t=2014. Cilioplasm is a cellular compartment for calcium signaling in response to mechanical and chemical stimuli |pdf=|usr=}}{{24104765 }} gab.com Text Cilioplasm is a cellular compartment for calcium signaling in response to mechanical and chemical stimuli JO: Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=24104765 #FOAvip Primary cilia with a diameter of ~200 nm have been implicated in development and disease. Calcium signaling within a primary cilium has never been directly visualized and has therefore remained a speculation. Fluid-shear stress and dopamine receptor type-5 (DR5) agonist are among the few stimuli that require cilia for intracellular calcium signal transduction. However, it is not known if these stimuli initiate calcium signaling within the cilium or if the calcium signal originates in the cytoplasm. Using an integrated single-cell imaging technique, we demonstrate for the first time that calcium signaling triggered by fluid-shear stress initiates in the primary cilium and can be distinguished from the subsequent cytosolic calcium response through the ryanodine receptor. Importantly, this flow-induced calcium signaling depends on the ciliary polycystin-2 calcium channel. While DR5-specific agonist induces calcium signaling mainly in the cilioplasm via ciliary CaV1.2, thrombin specifically induces cytosolic calcium signaling through the IP3 receptor. Furthermore, a non-specific calcium ionophore triggers both ciliary and cytosolic calcium responses. We suggest that cilia not only act as sensory organelles but also function as calcium signaling compartments. Cilium-dependent signaling can spread to the cytoplasm or be contained within the cilioplasm. Our study thus provides the first model to understand signaling within the cilioplasm of a living cell. Twit Text FOAVip Cilioplasm is a cellular compartment for calcium signaling in response to mechanical and chemical stimuli ????Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=24104765 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24104765 #FOAvip English Wikipedia <ref>{{Cite pmid|24104765 }}</ref> Cilioplasm is a cellular compartment for calcium signaling in response to mechanical and chemical stimuli #MMPMID24104765 Jin X ; Mohieldin AM ; Muntean BS ; Green JA ; Shah JV ; Mykytyn K ; Nauli SM Cell Mol Life Sci 2014[Jun]; 71 (11 ): 2165-78 PMID24104765 show ga Primary cilia with a diameter of ~200 nm have been implicated in development and disease. Calcium signaling within a primary cilium has never been directly visualized and has therefore remained a speculation. Fluid-shear stress and dopamine receptor type-5 (DR5) agonist are among the few stimuli that require cilia for intracellular calcium signal transduction. However, it is not known if these stimuli initiate calcium signaling within the cilium or if the calcium signal originates in the cytoplasm. Using an integrated single-cell imaging technique, we demonstrate for the first time that calcium signaling triggered by fluid-shear stress initiates in the primary cilium and can be distinguished from the subsequent cytosolic calcium response through the ryanodine receptor. Importantly, this flow-induced calcium signaling depends on the ciliary polycystin-2 calcium channel. While DR5-specific agonist induces calcium signaling mainly in the cilioplasm via ciliary CaV1.2, thrombin specifically induces cytosolic calcium signaling through the IP3 receptor. Furthermore, a non-specific calcium ionophore triggers both ciliary and cytosolic calcium responses. We suggest that cilia not only act as sensory organelles but also function as calcium signaling compartments. Cilium-dependent signaling can spread to the cytoplasm or be contained within the cilioplasm. Our study thus provides the first model to understand signaling within the cilioplasm of a living cell. |*Calcium Signaling [MESH] |*Mechanotransduction, Cellular [MESH] |Animals [MESH] |Calcium Channels, L-Type/genetics/metabolism [MESH] |Calcium Ionophores/pharmacology [MESH] |Cilia/drug effects/*metabolism [MESH] |Cytoplasm/drug effects/metabolism [MESH] |Epithelial Cells/cytology/drug effects/*metabolism [MESH] |Gene Expression Regulation [MESH] |Inositol 1,4,5-Trisphosphate Receptors/genetics/metabolism [MESH] |Kidney/cytology/drug effects/metabolism [MESH] |Molecular Imaging [MESH] |Primary Cell Culture [MESH] |Receptors, TNF-Related Apoptosis-Inducing Ligand/genetics/metabolism [MESH] |Rheology [MESH] |Ryanodine Receptor Calcium Release Channel/genetics/metabolism [MESH] |Single-Cell Analysis [MESH] |Stress, Mechanical [MESH] |Swine [MESH] |TRPP Cation Channels/genetics/*metabolism [MESH]Cilioplasm is a cellular compartment for calcium signaling in response(epmc).pdf DeepDyve Pubget Overpricing