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10.1002/cncr.28551 http://scihub22266oqcxt.onion/10.1002/cncr.28551 C3981875!3981875!24390809     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer 2014 ; 120 (8): 1228-36 Nephropedia Template TP {{tp|p=24390809|t=2014. Elevated Levels of Mitochondrion-associated Autophagy Inhibitor LRPPRC Are Associated with Poor Prognosis of Human Patients with Prostate Cancer |pdf=|usr=}}{{24390809}} gab.com Text Elevated Levels of Mitochondrion-associated Autophagy Inhibitor LRPPRC Are Associated with Poor Prognosis of Human Patients with Prostate Cancer JO: Cancer http://www.kidney.de/pget.php?&tw=1&pmid=24390809 #FOAvip BACKGROUND: Autophagy has recently been found to play important roles in tumorigenesis and LRPPRC has been identified as an inhibitor that suppresses autophagy and mitophagy and maintains mitochondrial activity. We hypothesized that LRPPRC levels can be used as a biomarker for diagnosis and prognosis of prostate cancer. METHODS: We performed immunochemistry analysis to evaluate the levels of LRPPRC in 112 samples collected from patients with prostate adenocarcinomas (PCa) and 38 samples from patients with benign prostate hyperplasia (BPH) enrolled in hospitals in Guangzhou city of China that have been followed up for 10 years. RESULTS: We found that there were significant higher levels of LRPPRC in PCa than in BPH. More than three quarters of PCa patients showed high levels of LRPPRC while only 10% of BPH patients had similar levels of LRPPRC. The levels of LRPPRC protein were positively correlated with tumor grade, metastasis and serum PSA, but negatively correlated with hormone therapy sensitivity after 2 years of surgery and overall survival. The association of high levels of LRPPRC with late stage of PCa or hormone therapy insensitivity was confirmed in tissue samples collected from prostate-specific PTEN?/? mice or hormone-dependent and independent prostate cancer cell lines. CONCLUSION: The levels of LRPPRC may be used as an independent biomarker for PCa patients at late-stage with poor prognosis. Twit Text FOAVip Elevated Levels of Mitochondrion-associated Autophagy Inhibitor LRPPRC Are Associated with Poor Prognosis of Human Patients with Prostate Cancer ????Cancer http://www.kidney.de/pget.php?&tw=1&pmid=24390809 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24390809 #FOAvip English Wikipedia <ref>{{Cite pmid|24390809}}</ref> Elevated Levels of Mitochondrion-associated Autophagy Inhibitor LRPPRC Are Associated with Poor Prognosis of Human Patients with Prostate Cancer #MMPMID24390809 Jiang X; Li X; Huang H; Jiang F; Lin Z; He H; Chen Y; Yue F; Zou J; He Y; You P; Wang W; Yang W; Zhao H; Lai Y; Wang F; Zhong W; Liu L Cancer 2014[Apr]; 120 (8): 1228-36 PMID24390809show ga BACKGROUND: Autophagy has recently been found to play important roles in tumorigenesis and LRPPRC has been identified as an inhibitor that suppresses autophagy and mitophagy and maintains mitochondrial activity. We hypothesized that LRPPRC levels can be used as a biomarker for diagnosis and prognosis of prostate cancer. METHODS: We performed immunochemistry analysis to evaluate the levels of LRPPRC in 112 samples collected from patients with prostate adenocarcinomas (PCa) and 38 samples from patients with benign prostate hyperplasia (BPH) enrolled in hospitals in Guangzhou city of China that have been followed up for 10 years. RESULTS: We found that there were significant higher levels of LRPPRC in PCa than in BPH. More than three quarters of PCa patients showed high levels of LRPPRC while only 10% of BPH patients had similar levels of LRPPRC. The levels of LRPPRC protein were positively correlated with tumor grade, metastasis and serum PSA, but negatively correlated with hormone therapy sensitivity after 2 years of surgery and overall survival. The association of high levels of LRPPRC with late stage of PCa or hormone therapy insensitivity was confirmed in tissue samples collected from prostate-specific PTEN?/? mice or hormone-dependent and independent prostate cancer cell lines. CONCLUSION: The levels of LRPPRC may be used as an independent biomarker for PCa patients at late-stage with poor prognosis. äElevated Levels of Mitochondrion-associated Autophagy Inhibitor LRPPRC(epmc).pdf DeepDyve Pubget Overpricing