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Cancer
2014 ; 120
(8
): 1228-36
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Elevated levels of mitochondrion-associated autophagy inhibitor LRPPRC are
associated with poor prognosis in patients with prostate cancer
#MMPMID24390809
Jiang X
; Li X
; Huang H
; Jiang F
; Lin Z
; He H
; Chen Y
; Yue F
; Zou J
; He Y
; You P
; Wang W
; Yang W
; Zhao H
; Lai Y
; Wang F
; Zhong W
; Liu L
Cancer
2014[Apr]; 120
(8
): 1228-36
PMID24390809
show ga
BACKGROUND: Autophagy has recently been found to play important roles in
tumorigenesis and leucine-rich pentatricopeptide repeat motif-containing protein
(LRPPRC) has been identified as an inhibitor that suppresses autophagy and
mitophagy and maintains mitochondrial activity. The authors hypothesized that
LRPPRC levels can be used as a biomarker for the diagnosis and prognosis of
prostate cancer. METHODS: Immunochemistry analysis was performed to evaluate the
levels of LRPPRC in 112 samples collected from patients with prostate
adenocarcinoma (PCa) and 38 samples from patients with benign prostatic
hyperplasia (BPH) who were enrolled in hospitals in Guangzhou City, China and
were followed for 10 years. RESULTS: Significantly higher levels of LRPPRC were
found in PCa samples compared with BPH samples. Greater than 75% of patients with
PCa demonstrated high levels of LRPPRC whereas only 10% of patients with BPH were
found to have similar levels of LRPPRC. The levels of LRPPRC were found to be
positively correlated with tumor grade, metastasis, and serum prostate-specific
antigen level, but were negatively correlated with hormone therapy sensitivity
after 2 years of surgery and overall survival. The association between high
levels of LRPPRC and late-stage PCa or hormone therapy insensitivity was
confirmed in tissue samples collected from prostate-specific phosphatase and
tensin homolog (PTEN)(-/-) mice or hormone-dependent and hormone-independent PCa
cell lines. CONCLUSIONS: LRPPRC levels may be used as an independent biomarker
for patients with PCa at a late stage with poor prognosis.
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