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10.1073/pnas.93.6.2448 http://scihub22266oqcxt.onion/10.1073/pnas.93.6.2448 C39817!39817 !8637894     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=8637894 &cmd=llinks): Failed to open stream: HTTP request failed! 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Pathogenesis of influenza virus-induced pneumonia: involvement of both nitric oxide and oxygen radicals |pdf=|usr=}}{{8637894 }} gab.com Text Pathogenesis of influenza virus-induced pneumonia: involvement of both nitric oxide and oxygen radicals JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=8637894 #FOAvip The role of nitric oxide (NO) in the pathogenesis of influenza virus-induced pneumonia in mice was investigated. Experimental influenza virus pneumonia was produced with influenza virus A/Kumamoto/Y5/67(H2N2). Both the enzyme activity of NO synthase (NOS) and mRNA expression of the inducible NOS were greatly increased in the mouse lungs; increases were mediated by interferon gamma. Excessive production of NO in the virus-infected lung was studied further by using electron spin resonance (ESR) spectroscopy. In vivo spin trapping with dithiocarbamate-iron complexes indicated that a significant amount of NO was generated in the virus-infected lung. Furthermore, an NO-hemoglobin ESR signal appeared in the virus-infected lung, and formation of NO-hemoglobin was significantly increased by treatment with superoxide dismutase and was inhibited by N(omega)-monomethyl-L-arginine (L-NMMA) administration. Immunohistochemistry with a specific anti-nitrotyrosine antibody showed intense staining of alveolar phagocytic cells such as macrophages and neutrophils and of intraalveolar exudate in the virus-infected lung. These results strongly suggest formation of peroxynitrite in the lung through the reaction of NO with O2-, which is generated by alveolar phagocytic cells and xanthine oxidase. In addition, administration of L-NMMA resulted in significant improvement in the survival rate of virus-infected mice without appreciable suppression of their antiviral defenses. On the basis of these data, we conclude that NO together with O2- which forms more reactive peroxynitrite may be the most important pathogenic factors in influenza virus-induced pneumonia in mice. Twit Text FOAVip Pathogenesis of influenza virus-induced pneumonia: involvement of both nitric oxide and oxygen radicals ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=8637894 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=8637894 #FOAvip English Wikipedia <ref>{{Cite pmid|8637894 }}</ref> Pathogenesis of influenza virus-induced pneumonia: involvement of both nitric oxide and oxygen radicals #MMPMID8637894 Akaike T ; Noguchi Y ; Ijiri S ; Setoguchi K ; Suga M ; Zheng YM ; Dietzschold B ; Maeda H Proc Natl Acad Sci U S A 1996[Mar]; 93 (6 ): 2448-53 PMID8637894 show ga The role of nitric oxide (NO) in the pathogenesis of influenza virus-induced pneumonia in mice was investigated. Experimental influenza virus pneumonia was produced with influenza virus A/Kumamoto/Y5/67(H2N2). Both the enzyme activity of NO synthase (NOS) and mRNA expression of the inducible NOS were greatly increased in the mouse lungs; increases were mediated by interferon gamma. Excessive production of NO in the virus-infected lung was studied further by using electron spin resonance (ESR) spectroscopy. In vivo spin trapping with dithiocarbamate-iron complexes indicated that a significant amount of NO was generated in the virus-infected lung. Furthermore, an NO-hemoglobin ESR signal appeared in the virus-infected lung, and formation of NO-hemoglobin was significantly increased by treatment with superoxide dismutase and was inhibited by N(omega)-monomethyl-L-arginine (L-NMMA) administration. Immunohistochemistry with a specific anti-nitrotyrosine antibody showed intense staining of alveolar phagocytic cells such as macrophages and neutrophils and of intraalveolar exudate in the virus-infected lung. These results strongly suggest formation of peroxynitrite in the lung through the reaction of NO with O2-, which is generated by alveolar phagocytic cells and xanthine oxidase. In addition, administration of L-NMMA resulted in significant improvement in the survival rate of virus-infected mice without appreciable suppression of their antiviral defenses. On the basis of these data, we conclude that NO together with O2- which forms more reactive peroxynitrite may be the most important pathogenic factors in influenza virus-induced pneumonia in mice. |Animals [MESH] |Arginine/analogs & derivatives/pharmacology [MESH] |Electron Spin Resonance Spectroscopy [MESH] |Enzyme Induction [MESH] |Enzyme Inhibitors/pharmacology [MESH] |Free Radicals [MESH] |Influenza A virus/pathogenicity [MESH] |Interferon-gamma/physiology [MESH] |Lung/metabolism [MESH] |Male [MESH] |Mice [MESH] |Nitric Oxide Synthase/antagonists & inhibitors/biosynthesis [MESH] |Nitric Oxide/*metabolism [MESH] |Pneumonia, Viral/*physiopathology [MESH] |Reactive Oxygen Species/*metabolism [MESH] |Superoxides/metabolism [MESH]Pathogenesis of influenza virus-induced pneumonia: involvement of both(epmc).pdf DeepDyve Pubget Overpricing