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10.1097/FJC.0000000000000032 http://scihub22266oqcxt.onion/10.1097/FJC.0000000000000032 C3980029!3980029 !24145181     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24145181 &cmd=llinks): Failed to open stream: HTTP request failed! 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Alpha-1-adrenergic receptors in heart failure: the adaptive arm of the cardiac response to chronic catecholamine stimulation |pdf=|usr=}}{{24145181 }} gab.com Text Alpha-1-adrenergic receptors in heart failure: the adaptive arm of the cardiac response to chronic catecholamine stimulation JO: J Cardiovasc Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=24145181 #FOAvip Alpha-1-adrenergic receptors (ARs) are G protein-coupled receptors activated by catecholamines. The alpha-1A and alpha-1B subtypes are expressed in mouse and human myocardium, whereas the alpha-1D protein is found only in coronary arteries. There are far fewer alpha-1-ARs than beta-ARs in the nonfailing heart, but their abundance is maintained or increased in the setting of heart failure, which is characterized by pronounced chronic elevation of catecholamines and beta-AR dysfunction. Decades of evidence from gain and loss-of-function studies in isolated cardiac myocytes and numerous animal models demonstrate important adaptive functions for cardiac alpha-1-ARs to include physiological hypertrophy, positive inotropy, ischemic preconditioning, and protection from cell death. Clinical trial data indicate that blocking alpha-1-ARs is associated with incident heart failure in patients with hypertension. Collectively, these findings suggest that alpha-1-AR activation might mitigate the well-recognized toxic effects of beta-ARs in the hyperadrenergic setting of chronic heart failure. Thus, exogenous cardioselective activation of alpha-1-ARs might represent a novel and viable approach to the treatment of heart failure. Twit Text FOAVip Alpha-1-adrenergic receptors in heart failure: the adaptive arm of the cardiac response to chronic catecholamine stimulation ????J Cardiovasc Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=24145181 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24145181 #FOAvip English Wikipedia <ref>{{Cite pmid|24145181 }}</ref> Alpha-1-adrenergic receptors in heart failure: the adaptive arm of the cardiac response to chronic catecholamine stimulation #MMPMID24145181 Jensen BC ; O?Connell TD ; Simpson PC J Cardiovasc Pharmacol 2014[Apr]; 63 (4 ): 291-301 PMID24145181 show ga Alpha-1-adrenergic receptors (ARs) are G protein-coupled receptors activated by catecholamines. The alpha-1A and alpha-1B subtypes are expressed in mouse and human myocardium, whereas the alpha-1D protein is found only in coronary arteries. There are far fewer alpha-1-ARs than beta-ARs in the nonfailing heart, but their abundance is maintained or increased in the setting of heart failure, which is characterized by pronounced chronic elevation of catecholamines and beta-AR dysfunction. Decades of evidence from gain and loss-of-function studies in isolated cardiac myocytes and numerous animal models demonstrate important adaptive functions for cardiac alpha-1-ARs to include physiological hypertrophy, positive inotropy, ischemic preconditioning, and protection from cell death. Clinical trial data indicate that blocking alpha-1-ARs is associated with incident heart failure in patients with hypertension. Collectively, these findings suggest that alpha-1-AR activation might mitigate the well-recognized toxic effects of beta-ARs in the hyperadrenergic setting of chronic heart failure. Thus, exogenous cardioselective activation of alpha-1-ARs might represent a novel and viable approach to the treatment of heart failure. |Adrenergic alpha-1 Receptor Antagonists/adverse effects [MESH] |Animals [MESH] |Catecholamines/*physiology [MESH] |Heart Failure/drug therapy/genetics/*physiopathology [MESH] |Heart/*physiopathology [MESH] |Humans [MESH] |Mice [MESH] |Mice, Knockout [MESH]Alpha-1-adrenergic receptors in heart failure: the adaptive arm of the(epmc).pdf DeepDyve Pubget Overpricing