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10.4049/jimmunol.1302601 http://scihub22266oqcxt.onion/10.4049/jimmunol.1302601 C3979985!3979985!24634493     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2014 ; 192 (8): 3889-97 Nephropedia Template TP {{tp|p=24634493|t=2014. Functional NK cell repertoires are maintained through IL-2R? and FasL |pdf=|usr=}}{{24634493}} gab.com Text Functional NK cell repertoires are maintained through IL-2R and FasL JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24634493 #FOAvip Acquisition of a functional natural killer (NK) cell repertoire, known as education or licensing, is a complex process mediated through inhibitory receptors that recognize self. We found that NK cells containing self-killer immunoglobulin-like receptors (KIR) for cognate HLA-ligand in vivo were less susceptible to apoptosis. In vitro IL-15 withdrawal showed that uneducated NK cells upregulated Bim and Fas. Conversely, educated NK cells upregulated FasL under these conditions. Induction of cell death and Bim expression on uneducated cells correlated with increased IL-2R? expression. Overexpression and knockdown studies showed that higher IL-2R? limits NK cell survival in a novel manner that is independent from the role of IL-2 in activation induced cell death (AICD). To study the role of FasL in induction of IL-2R?hi NK cell death, a co-culture assay with FasL blocking antibodies was used. IL-15 withdrawal led to FasL dependent killing of IL-2R?hi NK cells by more educated IL-2R?lo NK cells. Finally, CMV reactivation induces a potent long-lasting population of licensed NK cells with enhanced survival. These findings show education dependent NK cell survival advantages and killing of uneducated NK result in the maintenance of a functional repertoire, which may be manipulated to exploit NK cells for cancer immunotherapy. Twit Text FOAVip Functional NK cell repertoires are maintained through IL-2R and FasL ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24634493 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24634493 #FOAvip English Wikipedia <ref>{{Cite pmid|24634493}}</ref> Functional NK cell repertoires are maintained through IL-2R? and FasL #MMPMID24634493 Felices M; Lenvik TR; Ankarlo DE; Foley B; Curtsinger J; Luo X; Blazar BR; Anderson SK; Miller JS J Immunol 2014[Apr]; 192 (8): 3889-97 PMID24634493show ga Acquisition of a functional natural killer (NK) cell repertoire, known as education or licensing, is a complex process mediated through inhibitory receptors that recognize self. We found that NK cells containing self-killer immunoglobulin-like receptors (KIR) for cognate HLA-ligand in vivo were less susceptible to apoptosis. In vitro IL-15 withdrawal showed that uneducated NK cells upregulated Bim and Fas. Conversely, educated NK cells upregulated FasL under these conditions. Induction of cell death and Bim expression on uneducated cells correlated with increased IL-2R? expression. Overexpression and knockdown studies showed that higher IL-2R? limits NK cell survival in a novel manner that is independent from the role of IL-2 in activation induced cell death (AICD). To study the role of FasL in induction of IL-2R?hi NK cell death, a co-culture assay with FasL blocking antibodies was used. IL-15 withdrawal led to FasL dependent killing of IL-2R?hi NK cells by more educated IL-2R?lo NK cells. Finally, CMV reactivation induces a potent long-lasting population of licensed NK cells with enhanced survival. These findings show education dependent NK cell survival advantages and killing of uneducated NK result in the maintenance of a functional repertoire, which may be manipulated to exploit NK cells for cancer immunotherapy. äFunctional NK cell repertoires are maintained through IL-2R? and FasL (epmc).pdf DeepDyve Pubget Overpricing