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10.1016/j.coi.2014.01.013

http://scihub22266oqcxt.onion/10.1016/j.coi.2014.01.013
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C3979357!3979357!24594491
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suck abstract from ncbi


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pmid24594491      Curr+Opin+Immunol 2014 ; ä (ä): 75-82
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  • Regulation of the adaptive immune system by innate lymphoid cells #MMPMID24594491
  • Hepworth MR; Sonnenberg GF
  • Curr Opin Immunol 2014[Apr]; ä (ä): 75-82 PMID24594491show ga
  • Innate lymphoid cells (ILCs) are a group of lymphocytes that promote rapid cytokine-dependent innate immunity, inflammation and tissue repair. In addition, a growing body of evidence suggests ILCs can influence adaptive immune cell responses. During fetal development a subset of ILCs orchestrate the generation and maturation of secondary lymphoid tissues. Following birth, ILCs continue to modulate adaptive immune cell responses indirectly through interactions with stromal cells in lymphoid tissues and epithelial cells at barrier surfaces. In this review we summarize the current understanding of how ILCs modulate the magnitude and quality of adaptive immune cell responses, and in particular focus on recent evidence suggesting that ILCs can also directly regulate CD4+ T cells. Further, we discuss the implications that these pathways may have on human health and disease.
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