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10.1038/cr.2014.34 http://scihub22266oqcxt.onion/10.1038/cr.2014.34 C3975507!3975507!24662486     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Res 2014 ; 24 (4): 433-50 Nephropedia Template TP {{tp|p=24662486|t=2014. PKC? regulates Notch receptor routing and activity in a Notch signaling-dependent manner |pdf=|usr=}}{{24662486}} gab.com Text PKC regulates Notch receptor routing and activity in a Notch signaling-dependent manner JO: Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=24662486 #FOAvip Activation of Notch signaling requires intracellular routing of the receptor, but the mechanisms controlling the distinct steps in the routing process is poorly understood. We identify PKC? as a key regulator of Notch receptor intracellular routing. When PKC? was inhibited in the developing chick central nervous system and in cultured myoblasts, Notch-stimulated cells were allowed to undergo differentiation. PKC? phosphorylates membrane-tethered forms of Notch and regulates two distinct routing steps, depending on the Notch activation state. When Notch is activated, PKC? promotes re-localization of Notch from late endosomes to the nucleus and enhances production of the Notch intracellular domain, which leads to increased Notch activity. In the non-activated state, PKC? instead facilitates Notch receptor internalization, accompanied with increased ubiquitylation and interaction with the endosomal sorting protein Hrs. Collectively, these data identify PKC? as a key regulator of Notch trafficking and demonstrate that distinct steps in intracellular routing are differentially modulated depending on Notch signaling status. Twit Text FOAVip PKC regulates Notch receptor routing and activity in a Notch signaling-dependent manner ????Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=24662486 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24662486 #FOAvip English Wikipedia <ref>{{Cite pmid|24662486}}</ref> PKC? regulates Notch receptor routing and activity in a Notch signaling-dependent manner #MMPMID24662486 Sjöqvist M; Antfolk D; Ferraris S; Rraklli V; Haga C; Antila C; Mutvei A; Imanishi SY; Holmberg J; Jin S; Eriksson JE; Lendahl U; Sahlgren C Cell Res 2014[Apr]; 24 (4): 433-50 PMID24662486show ga Activation of Notch signaling requires intracellular routing of the receptor, but the mechanisms controlling the distinct steps in the routing process is poorly understood. We identify PKC? as a key regulator of Notch receptor intracellular routing. When PKC? was inhibited in the developing chick central nervous system and in cultured myoblasts, Notch-stimulated cells were allowed to undergo differentiation. PKC? phosphorylates membrane-tethered forms of Notch and regulates two distinct routing steps, depending on the Notch activation state. When Notch is activated, PKC? promotes re-localization of Notch from late endosomes to the nucleus and enhances production of the Notch intracellular domain, which leads to increased Notch activity. In the non-activated state, PKC? instead facilitates Notch receptor internalization, accompanied with increased ubiquitylation and interaction with the endosomal sorting protein Hrs. Collectively, these data identify PKC? as a key regulator of Notch trafficking and demonstrate that distinct steps in intracellular routing are differentially modulated depending on Notch signaling status. äPKC? regulates Notch receptor routing and activity in a Notch signalin(epmc).pdf DeepDyve Pubget Overpricing