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10.1038/cr.2014.17 http://scihub22266oqcxt.onion/10.1038/cr.2014.17 C3975499!3975499!24513853     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Res 2014 ; 24 (4): 417-32 Nephropedia Template TP {{tp|p=24513853|t=2014. The G??-Src signaling pathway regulates TNF-induced necroptosis via control of necrosome translocation |pdf=|usr=}}{{24513853}} gab.com Text The G -Src signaling pathway regulates TNF-induced necroptosis via control of necrosome translocation JO: Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=24513853 #FOAvip Formation of multi-component signaling complex necrosomes is essential for tumor necrosis factor ? (TNF)-induced programmed necrosis (also called necroptosis). However, the mechanisms of necroptosis are still largely unknown. We isolated a TNF-resistant L929 mutant cell line generated by retrovirus insertion and identified that disruption of the guanine nucleotide-binding protein ? 10 (G?10) gene is responsible for this phenotype. We further show that G?10 is involved in TNF-induced necroptosis and G?2 is the partner of G?10. Src is the downstream effector of G?2?10 in TNF-induced necroptosis because TNF-induced Src activation was impaired upon G?10 knockdown. G?10 does not affect TNF-induced activation of NF-?B and MAPKs and the formation of necrosomes, but is required for trafficking of necrosomes to their potential functioning site, an unidentified subcellular organelle that can be fractionated into heterotypic membrane fractions. The TNF-induced G??-Src signaling pathway is independent of RIP1/RIP3 kinase activity and necrosome formation, but is required for the necrosome to function. Twit Text FOAVip The G -Src signaling pathway regulates TNF-induced necroptosis via control of necrosome translocation ????Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=24513853 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24513853 #FOAvip English Wikipedia <ref>{{Cite pmid|24513853}}</ref> The G??-Src signaling pathway regulates TNF-induced necroptosis via control of necrosome translocation #MMPMID24513853 Li L; Chen W; Liang Y; Ma H; Li W; Zhou Z; Li J; Ding Y; Ren J; Lin J; Han F; Wu J; Han J Cell Res 2014[Apr]; 24 (4): 417-32 PMID24513853show ga Formation of multi-component signaling complex necrosomes is essential for tumor necrosis factor ? (TNF)-induced programmed necrosis (also called necroptosis). However, the mechanisms of necroptosis are still largely unknown. We isolated a TNF-resistant L929 mutant cell line generated by retrovirus insertion and identified that disruption of the guanine nucleotide-binding protein ? 10 (G?10) gene is responsible for this phenotype. We further show that G?10 is involved in TNF-induced necroptosis and G?2 is the partner of G?10. Src is the downstream effector of G?2?10 in TNF-induced necroptosis because TNF-induced Src activation was impaired upon G?10 knockdown. G?10 does not affect TNF-induced activation of NF-?B and MAPKs and the formation of necrosomes, but is required for trafficking of necrosomes to their potential functioning site, an unidentified subcellular organelle that can be fractionated into heterotypic membrane fractions. The TNF-induced G??-Src signaling pathway is independent of RIP1/RIP3 kinase activity and necrosome formation, but is required for the necrosome to function. äThe G??-Src signaling pathway regulates TNF-induced necroptosis via co(epmc).pdf DeepDyve Pubget Overpricing