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Helicobacter pylori-negative Russell body gastritis: does the diagnosis call for
screening for plasmacytic malignancies, especially multiple myeloma?
#MMPMID24671320
Klair JS
; Girotra M
; Kaur A
; Aduli F
BMJ Case Rep
2014[Mar]; 2014
(?): ? PMID24671320
show ga
Russell body gastritis (RBG) is a rare entity with unestablished pathophysiology,
endoscopic findings, clinical manifestations and treatments. Literature is scarce
on this clinical entity with unclear clinical significance. Of 18 cases reported,
12 tested (+) for Helicobacter pylori and improved with treatment, but it remains
unclear whether this link is coincidental or bears some clinical significance. We
describe a case of elderly woman who had a follow-up oesophagogastroduodenoscopy
for chronic peptic ulcers, and biopsy showed positive immunohistochemical stains
for ? and ?, indicating a polytypic population of plasma cells. Immunostaining
for H pylori was negative. Biopsies were also (-) for gastric carcinoma, lymphoma
and plasmacytoma. Considering her RGB-suggestive histology and her symptoms of
bone pains and anaemia, multiple myeloma screening was considered clinically
relevant. The purpose of this review was to educate clinicians and
gastroenterologists about this unique entity and explore its association with
multiple myeloma or other plamacytic malignancies.
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