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10.1074/jbc.M113.545822 http://scihub22266oqcxt.onion/10.1074/jbc.M113.545822 C3975039!3975039 !24550394     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24550394 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       J+Biol+Chem 2014 ; 289 (14 ): 9952-60 Nephropedia Template TP {{tp|p=24550394 |t=2014. Interleukin-6 (IL-6) trans signaling drives a STAT3-dependent pathway that leads to hyperactive transforming growth factor-? (TGF-?) signaling promoting SMAD3 activation and fibrosis via Gremlin protein |pdf=|usr=}}{{24550394 }} gab.com Text Interleukin-6 (IL-6) trans signaling drives a STAT3-dependent pathway that leads to hyperactive transforming growth factor- (TGF- ) signaling promoting SMAD3 activation and fibrosis via Gremlin protein JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=24550394 #FOAvip Fibrosis is a common and intractable condition associated with various pathologies. It is characterized by accumulation of an excessive amount of extracellular matrix molecules that primarily include collagen type I. IL-6 is a profibrotic cytokine that is elevated in the prototypic fibrotic autoimmune condition systemic sclerosis and is known to induce collagen I expression, but the mechanism(s) behind this induction are currently unknown. Using healthy dermal fibroblasts in vitro, we analyzed the signaling pathways that underscore the IL-6-mediated induction of collagen. We show that IL-6 trans signaling is important and that the effect is dependent on STAT3; however, the effect is indirect and mediated through enhanced TGF-? signaling and the classic downstream cellular mediator Smad3. This is due to induction of the bone morphogenetic protein (BMP) antagonist Gremlin-1, and we show that Gremlin-1 is profibrotic and is mediated through canonical TGF-? signaling. Twit Text FOAVip Interleukin-6 (IL-6) trans signaling drives a STAT3-dependent pathway that leads to hyperactive transforming growth factor- (TGF- ) signaling promoting SMAD3 activation and fibrosis via Gremlin protein ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=24550394 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24550394 #FOAvip English Wikipedia <ref>{{Cite pmid|24550394 }}</ref> Interleukin-6 (IL-6) trans signaling drives a STAT3-dependent pathway that leads to hyperactive transforming growth factor-? (TGF-?) signaling promoting SMAD3 activation and fibrosis via Gremlin protein #MMPMID24550394 O'Reilly S ; Ciechomska M ; Cant R ; van Laar JM J Biol Chem 2014[Apr]; 289 (14 ): 9952-60 PMID24550394 show ga Fibrosis is a common and intractable condition associated with various pathologies. It is characterized by accumulation of an excessive amount of extracellular matrix molecules that primarily include collagen type I. IL-6 is a profibrotic cytokine that is elevated in the prototypic fibrotic autoimmune condition systemic sclerosis and is known to induce collagen I expression, but the mechanism(s) behind this induction are currently unknown. Using healthy dermal fibroblasts in vitro, we analyzed the signaling pathways that underscore the IL-6-mediated induction of collagen. We show that IL-6 trans signaling is important and that the effect is dependent on STAT3; however, the effect is indirect and mediated through enhanced TGF-? signaling and the classic downstream cellular mediator Smad3. This is due to induction of the bone morphogenetic protein (BMP) antagonist Gremlin-1, and we show that Gremlin-1 is profibrotic and is mediated through canonical TGF-? signaling. |*Signal Transduction [MESH] |Bone Morphogenetic Proteins/biosynthesis/genetics [MESH] |Cells, Cultured [MESH] |Collagen Type I/biosynthesis/genetics [MESH] |Female [MESH] |Fibroblasts/*metabolism/pathology [MESH] |Fibrosis/genetics/metabolism/pathology [MESH] |Humans [MESH] |Intercellular Signaling Peptides and Proteins/genetics/*metabolism [MESH] |Interleukin-6/genetics/*metabolism [MESH] |STAT3 Transcription Factor/genetics/*metabolism [MESH] |Smad3 Protein/genetics/*metabolism [MESH]Interleukin-6 (IL-6) trans signaling drives a STAT3-dependent pathway (epmc).pdf DeepDyve Pubget Overpricing