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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Biol+Chem 2014 ; 289 (14): 9692-709 Nephropedia Template TP
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The Metastasis Suppressor, N-myc Downstream-regulated Gene 1 (NDRG1), Inhibits Stress-induced Autophagy in Cancer Cells #MMPMID24532803
Sahni S; Bae DH; Lane DJR; Kovacevic Z; Kalinowski DS; Jansson PJ; Richardson DR
J Biol Chem 2014[Apr]; 289 (14): 9692-709 PMID24532803show ga
Background: NDRG1 is an important iron-regulated metastasis suppressor that plays an undefined role in the stress response.Results: We demonstrate that NDRG1 suppresses the stress-induced, pro-survival autophagic pathway.Conclusion: Suppression of the autophagic pathway by NDRG1 makes cells more susceptible to apoptosis.Significance: These results indicate an important new mechanism through which NDRG1 exerts its metastasis suppressor activity.