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10.1016/j.coi.2014.01.012 http://scihub22266oqcxt.onion/10.1016/j.coi.2014.01.012 C3972342!3972342!24549093     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Immunol 2014 ; ä (ä): 53-9 Nephropedia Template TP {{tp|p=24549093|t=2014. Dual immunoglobulin light chain B cells: Trojan horses of autoimmunity?|pdf=|usr=}}{{24549093}} gab.com Text Dual immunoglobulin light chain B cells: Trojan horses of autoimmunity JO: Curr Opin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24549093 #FOAvip Receptor editing, a major mechanism of B cell tolerance, can also lead to allelic inclusion at the immunoglobulin light chain loci and the development of B cells that co-express two different immunoglobulin light chains and, therefore, two antibody specificities. Most allelically included B cells express two ? chains, although rare dual-? cells are also observed. Moreover, these cells typically co-express an autoreactive and a nonautoreactive antibody. Thus, allelically included B cells could operate like ?Trojan horses?: expression and function of the nonautoreactive antigen receptors might promote their maturation, activation, and terminal differentiation into effector cells that also express and secrete autoantibodies. Indeed, dual-? B cells are greatly expanded into effector B cell subsets in some autoimmune mice, thus indicating they might play an important role in disease. Twit Text FOAVip Dual immunoglobulin light chain B cells: Trojan horses of autoimmunity ????Curr Opin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24549093 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24549093 #FOAvip English Wikipedia <ref>{{Cite pmid|24549093}}</ref> Dual immunoglobulin light chain B cells: Trojan horses of autoimmunity? #MMPMID24549093 Pelanda R Curr Opin Immunol 2014[Apr]; ä (ä): 53-9 PMID24549093show ga Receptor editing, a major mechanism of B cell tolerance, can also lead to allelic inclusion at the immunoglobulin light chain loci and the development of B cells that co-express two different immunoglobulin light chains and, therefore, two antibody specificities. Most allelically included B cells express two ? chains, although rare dual-? cells are also observed. Moreover, these cells typically co-express an autoreactive and a nonautoreactive antibody. Thus, allelically included B cells could operate like ?Trojan horses?: expression and function of the nonautoreactive antigen receptors might promote their maturation, activation, and terminal differentiation into effector cells that also express and secrete autoantibodies. Indeed, dual-? B cells are greatly expanded into effector B cell subsets in some autoimmune mice, thus indicating they might play an important role in disease. äDual immunoglobulin light chain B cells: Trojan horses of autoimmunity(epmc).pdf DeepDyve Pubget Overpricing