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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Neurosci+Lett 2014 ; ä (ä): 53-8 Nephropedia Template TP
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Mini-review: Neuroprotection by astrocytes in brain ischemia: importance of microRNAs #MMPMID24269978
Ouyang YB; Xu L; Yue S; Liu S; Giffard RG
Neurosci Lett 2014[Apr]; ä (ä): 53-8 PMID24269978show ga
Astrocytes have been shown to protect neurons and increase their survival in many pathological settings. Manipulating astrocyte functions is thus an important strategy to enhance neuronal survival and improve outcome following cerebral ischemia. Increasing evidence supports the involvement of microRNAs (miRNA), some of them being astrocyte-enriched, in the regulation of cerebral ischemia. This mini review will focus on several recently reported astrocyte-enriched miRNAs (miR-181 and miR-29 families and miR-146a), their validated targets, regional expression and effects on outcome after cerebral ischemia.