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10.1016/j.ajo.2013.12.026 http://scihub22266oqcxt.onion/10.1016/j.ajo.2013.12.026 C3972252!3972252 !24418264     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24418264 &cmd=llinks): Failed to open stream: HTTP request failed! 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Endophthalmitis caused by streptococcal species: clinical settings, microbiology, management, and outcomes |pdf=|usr=}}{{24418264 }} gab.com Text Endophthalmitis caused by streptococcal species: clinical settings, microbiology, management, and outcomes JO: Am J Ophthalmol http://www.kidney.de/pget.php?&tw=1&pmid=24418264 #FOAvip PURPOSE: To report the clinical settings, antibiotic susceptibilities, and outcomes of endophthalmitis caused by Streptococcus species. DESIGN: Retrospective, observational case series. METHODS: Single-center study evaluating all patients with culture-positive endophthalmitis caused by Streptococcus species between January 1, 2000, and December 31, 2011. RESULTS: Study criteria were met by 63 patients. The most common clinical settings were bleb associated (n = 17; 27%), after intravitreal injection (n = 16; 25%), and after cataract surgery (n = 13; 21%). The isolates were Streptococcus viridans (n = 47; 71%), Streptococcus pneumoniae (n = 13; 21%), and ?-hemolytic Streptococci (n = 5; 8%). Sixty (95%) of 63 isolates were susceptible to vancomycin, 47 (98%) of 48 isolates were susceptible to ceftriaxone (third-generation cephalosporin), and 57 (93%) of 61 isolates were susceptible to levofloxacin (third-generation fluoroquinolone). Between the first and second half of the study, the minimal inhibitory concentration of antibiotics required to inhibit 90% of isolates increased by 1.5-fold for ceftriaxone and 2-fold for levofloxacin and remained the same for vancomycin. Initial treatment was vitreous tap (49; 78%) or pars plana vitrectomy (14; 22%); all received intravitreal antibiotics. Visual acuity outcomes were variable: best-corrected visual acuity was 20/400 or better in 16 (25%) patients and worse than 20/400 in 47 (75%) patients. Evisceration or enucleation was performed in 16 (25%) patients. CONCLUSIONS: Streptococcus isolates generally had high susceptibility rates to commonly used antibiotics. Higher antibiotic minimal inhibitory concentrations were required to inhibit 90% of isolates in vitro in the second half of the study period compared with the first half. Despite prompt treatment, most patients had poor outcomes. Twit Text FOAVip Endophthalmitis caused by streptococcal species: clinical settings, microbiology, management, and outcomes ????Am J Ophthalmol http://www.kidney.de/pget.php?&tw=1&pmid=24418264 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24418264 #FOAvip English Wikipedia <ref>{{Cite pmid|24418264 }}</ref> Endophthalmitis caused by streptococcal species: clinical settings, microbiology, management, and outcomes #MMPMID24418264 Kuriyan AE ; Weiss KD ; Flynn HW Jr ; Smiddy WE ; Berrocal AM ; Albini TA ; Miller D Am J Ophthalmol 2014[Apr]; 157 (4 ): 774-780.e1 PMID24418264 show ga PURPOSE: To report the clinical settings, antibiotic susceptibilities, and outcomes of endophthalmitis caused by Streptococcus species. DESIGN: Retrospective, observational case series. METHODS: Single-center study evaluating all patients with culture-positive endophthalmitis caused by Streptococcus species between January 1, 2000, and December 31, 2011. RESULTS: Study criteria were met by 63 patients. The most common clinical settings were bleb associated (n = 17; 27%), after intravitreal injection (n = 16; 25%), and after cataract surgery (n = 13; 21%). The isolates were Streptococcus viridans (n = 47; 71%), Streptococcus pneumoniae (n = 13; 21%), and ?-hemolytic Streptococci (n = 5; 8%). Sixty (95%) of 63 isolates were susceptible to vancomycin, 47 (98%) of 48 isolates were susceptible to ceftriaxone (third-generation cephalosporin), and 57 (93%) of 61 isolates were susceptible to levofloxacin (third-generation fluoroquinolone). Between the first and second half of the study, the minimal inhibitory concentration of antibiotics required to inhibit 90% of isolates increased by 1.5-fold for ceftriaxone and 2-fold for levofloxacin and remained the same for vancomycin. Initial treatment was vitreous tap (49; 78%) or pars plana vitrectomy (14; 22%); all received intravitreal antibiotics. Visual acuity outcomes were variable: best-corrected visual acuity was 20/400 or better in 16 (25%) patients and worse than 20/400 in 47 (75%) patients. Evisceration or enucleation was performed in 16 (25%) patients. CONCLUSIONS: Streptococcus isolates generally had high susceptibility rates to commonly used antibiotics. Higher antibiotic minimal inhibitory concentrations were required to inhibit 90% of isolates in vitro in the second half of the study period compared with the first half. Despite prompt treatment, most patients had poor outcomes. |Adolescent [MESH] |Adult [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Amikacin/therapeutic use [MESH] |Anti-Bacterial Agents/*therapeutic use [MESH] |Ceftazidime/therapeutic use [MESH] |Child [MESH] |Child, Preschool [MESH] |Combined Modality Therapy [MESH] |Endophthalmitis/diagnosis/drug therapy/*microbiology [MESH] |Eye Infections, Bacterial/diagnosis/drug therapy/*microbiology [MESH] |Female [MESH] |Humans [MESH] |Intravitreal Injections [MESH] |Male [MESH] |Microbial Sensitivity Tests [MESH] |Middle Aged [MESH] |Retrospective Studies [MESH] |Streptococcal Infections/diagnosis/drug therapy/*microbiology [MESH] |Streptococcus pneumoniae/drug effects/isolation & purification [MESH] |Streptococcus/drug effects/isolation & purification [MESH] |Treatment Outcome [MESH] |Vancomycin/therapeutic use [MESH] |Viridans Streptococci/drug effects/isolation & purification [MESH] |Visual Acuity [MESH] |Vitrectomy [MESH]Endophthalmitis caused by streptococcal species: clinical settings, mi(epmc).pdf DeepDyve Pubget Overpricing