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10.1111/bcp.12220 http://scihub22266oqcxt.onion/10.1111/bcp.12220 C3971980!3971980 !23919835     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=23919835 &cmd=llinks): Failed to open stream: HTTP request failed! 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Pharmacogenetic-guided dosing of coumarin anticoagulants: algorithms for warfarin, acenocoumarol and phenprocoumon |pdf=|usr=}}{{23919835 }} gab.com Text Pharmacogenetic-guided dosing of coumarin anticoagulants: algorithms for warfarin, acenocoumarol and phenprocoumon JO: Br J Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=23919835 #FOAvip Coumarin derivatives, such as warfarin, acenocoumarol and phenprocoumon are frequently prescribed oral anticoagulants to treat and prevent thromboembolism. Because there is a large inter-individual and intra-individual variability in dose-response and a small therapeutic window, treatment with coumarin derivatives is challenging. Certain polymorphisms in CYP2C9 and VKORC1 are associated with lower dose requirements and a higher risk of bleeding. In this review we describe the use of different coumarin derivatives, pharmacokinetic characteristics of these drugs and differences amongst the coumarins. We also describe the current clinical challenges and the role of pharmacogenetic factors. These genetic factors are used to develop dosing algorithms and can be used to predict the right coumarin dose. The effectiveness of this new dosing strategy is currently being investigated in clinical trials. Twit Text FOAVip Pharmacogenetic-guided dosing of coumarin anticoagulants: algorithms for warfarin, acenocoumarol and phenprocoumon ????Br J Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=23919835 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23919835 #FOAvip English Wikipedia <ref>{{Cite pmid|23919835 }}</ref> Pharmacogenetic-guided dosing of coumarin anticoagulants: algorithms for warfarin, acenocoumarol and phenprocoumon #MMPMID23919835 Verhoef TI ; Redekop WK ; Daly AK ; van Schie RM ; de Boer A ; Maitland-van der Zee AH Br J Clin Pharmacol 2014[Apr]; 77 (4 ): 626-41 PMID23919835 show ga Coumarin derivatives, such as warfarin, acenocoumarol and phenprocoumon are frequently prescribed oral anticoagulants to treat and prevent thromboembolism. Because there is a large inter-individual and intra-individual variability in dose-response and a small therapeutic window, treatment with coumarin derivatives is challenging. Certain polymorphisms in CYP2C9 and VKORC1 are associated with lower dose requirements and a higher risk of bleeding. In this review we describe the use of different coumarin derivatives, pharmacokinetic characteristics of these drugs and differences amongst the coumarins. We also describe the current clinical challenges and the role of pharmacogenetic factors. These genetic factors are used to develop dosing algorithms and can be used to predict the right coumarin dose. The effectiveness of this new dosing strategy is currently being investigated in clinical trials. |*Algorithms [MESH] |*Drug Dosage Calculations [MESH] |*Pharmacogenetics/economics [MESH] |Acenocoumarol/*administration & dosage/pharmacokinetics [MESH] |Anticoagulants/*administration & dosage/pharmacokinetics [MESH] |Clinical Trials as Topic [MESH] |Cost-Benefit Analysis [MESH] |Cytochrome P-450 CYP2C9/genetics [MESH] |Genotype [MESH] |Humans [MESH] |Phenprocoumon/*administration & dosage/pharmacokinetics [MESH] |Vitamin K Epoxide Reductases/genetics [MESH]Pharmacogenetic-guided dosing of coumarin anticoagulants: algorithms f(epmc).pdf DeepDyve Pubget Overpricing