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10.1093/infdis/jiu013 http://scihub22266oqcxt.onion/10.1093/infdis/jiu013 C3969552!3969552 !24403561     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24403561 &cmd=llinks): Failed to open stream: HTTP request failed! 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Human classical monocytes control the intracellular stage of Leishmania braziliensis by reactive oxygen species |pdf=|usr=}}{{24403561 }} gab.com Text Human classical monocytes control the intracellular stage of Leishmania braziliensis by reactive oxygen species JO: J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=24403561 #FOAvip Leishmania braziliensis are intracellular parasites that cause unique clinical forms of cutaneous leishmaniasis. Previous studies with other leishmania species demonstrated that reactive oxygen species (ROS) control promastigotes, the infective stage of the parasite, but not the amastigote form that exists in the mammalian host. Here we show that ROS inhibits growth of L. braziliensis amastigotes in resting monocytes, and that classical monocytes are primarily responsible for this control. ROS, but not nitric oxide, also contributed to killing of L. braziliensis by IFN-? activated monocytes. Furthermore, by gene expression profiling of human lesions we found greater expression of genes associated with ROS, but not nitric oxide, compared to normal skin. This study shows that ROS are important for control of L. braziliensis both at the initial stages of infection, as well as at later time points, and highlights that monocyte subsets may play different roles during leishmaniasis. Twit Text FOAVip Human classical monocytes control the intracellular stage of Leishmania braziliensis by reactive oxygen species ????J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=24403561 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24403561 #FOAvip English Wikipedia <ref>{{Cite pmid|24403561 }}</ref> Human classical monocytes control the intracellular stage of Leishmania braziliensis by reactive oxygen species #MMPMID24403561 Novais FO ; Nguyen BT ; Beiting DP ; Carvalho LP ; Glennie ND ; Passos S ; Carvalho EM ; Scott P J Infect Dis 2014[Apr]; 209 (8 ): 1288-96 PMID24403561 show ga Leishmania braziliensis are intracellular parasites that cause unique clinical forms of cutaneous leishmaniasis. Previous studies with other leishmania species demonstrated that reactive oxygen species (ROS) control promastigotes, the infective stage of the parasite, but not the amastigote form that exists in the mammalian host. Here we show that ROS inhibits growth of L. braziliensis amastigotes in resting monocytes, and that classical monocytes are primarily responsible for this control. ROS, but not nitric oxide, also contributed to killing of L. braziliensis by IFN-? activated monocytes. Furthermore, by gene expression profiling of human lesions we found greater expression of genes associated with ROS, but not nitric oxide, compared to normal skin. This study shows that ROS are important for control of L. braziliensis both at the initial stages of infection, as well as at later time points, and highlights that monocyte subsets may play different roles during leishmaniasis. |Animals [MESH] |Flow Cytometry [MESH] |Gene Expression Profiling [MESH] |Humans [MESH] |Leishmania braziliensis/*physiology [MESH] |Leishmaniasis, Cutaneous/metabolism/*prevention & control [MESH] |Monocytes/metabolism/*parasitology [MESH] |Nitric Oxide/metabolism [MESH] |Oligonucleotide Array Sequence Analysis [MESH] |Pennsylvania [MESH]Human classical monocytes control the intracellular stage of Leishmani(epmc).pdf DeepDyve Pubget Overpricing