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10.1007/s00467-013-2629-y http://scihub22266oqcxt.onion/10.1007/s00467-013-2629-y C3969418!3969418!24077661     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pediatr+Nephrol 2014 ; 29 (4): 621-7 Nephropedia Template TP {{tp|p=24077661|t=2014. The Mdm2-p53 pathway: multiple roles in kidney development |pdf=|usr=}}{{24077661}} gab.com Text The Mdm2-p53 pathway: multiple roles in kidney development JO: Pediatr Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=24077661 #FOAvip The molecular basis of nephron progenitor cell renewal and differentiation into nascent epithelial nephrons is an area of intense investigation. Defects in these early stages of nephrogenesis lead to renal hypoplasia, and eventually hypertension and chronic kidney disease. Terminal nephron differentiation, the process by which renal epithelial precursors cells exit the cell cycle and acquire physiological functions is equally important. Failure of terminal epithelial cell differentiation results in renal dysplasia and cystogenesis. Thus, a better understanding of the transcriptional frameworks which regulate early and late renal cell differentiation is of great clinical significance. In this review, we will discuss evidence implicating the Mdm2-p53 pathway in cell fate determination during development. The emerging central theme from loss- and gain-of-function studies is that tight regulation of p53 levels and transcriptional activity is absolutely required for nephrogenesis. We will also discuss how post-translational modifications of p53 (e.g., acetylation and phosphorylation) alter the spatiotemporal and functional properties of p53 and thus cell fate during kidney development. Mutations and polymorphisms in the Mdm2-p53 pathway are present in more than 50% of cancers in humans. This raises the question of whether sequence variants in the Mdm2-p53 pathway increase the susceptibility to renal dysgenesis, hypertension or chronic kidney disease. With the advent of whole exome sequencing and other high throughput technologies, this hypothesis is testable in cohorts of children with renal dysgenesis. Twit Text FOAVip The Mdm2-p53 pathway: multiple roles in kidney development ????Pediatr Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=24077661 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24077661 #FOAvip English Wikipedia <ref>{{Cite pmid|24077661}}</ref> The Mdm2-p53 pathway: multiple roles in kidney development #MMPMID24077661 El-Dahr SS; Hilliard S; Aboudehen K; Saifudeen Z Pediatr Nephrol 2014[Apr]; 29 (4): 621-7 PMID24077661show ga The molecular basis of nephron progenitor cell renewal and differentiation into nascent epithelial nephrons is an area of intense investigation. Defects in these early stages of nephrogenesis lead to renal hypoplasia, and eventually hypertension and chronic kidney disease. Terminal nephron differentiation, the process by which renal epithelial precursors cells exit the cell cycle and acquire physiological functions is equally important. Failure of terminal epithelial cell differentiation results in renal dysplasia and cystogenesis. Thus, a better understanding of the transcriptional frameworks which regulate early and late renal cell differentiation is of great clinical significance. In this review, we will discuss evidence implicating the Mdm2-p53 pathway in cell fate determination during development. The emerging central theme from loss- and gain-of-function studies is that tight regulation of p53 levels and transcriptional activity is absolutely required for nephrogenesis. We will also discuss how post-translational modifications of p53 (e.g., acetylation and phosphorylation) alter the spatiotemporal and functional properties of p53 and thus cell fate during kidney development. Mutations and polymorphisms in the Mdm2-p53 pathway are present in more than 50% of cancers in humans. This raises the question of whether sequence variants in the Mdm2-p53 pathway increase the susceptibility to renal dysgenesis, hypertension or chronic kidney disease. With the advent of whole exome sequencing and other high throughput technologies, this hypothesis is testable in cohorts of children with renal dysgenesis. äThe Mdm2-p53 pathway: multiple roles in kidney development (epmc).pdf DeepDyve Pubget Overpricing