Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1093/ndt/gft537 http://scihub22266oqcxt.onion/10.1093/ndt/gft537 C3967834!3967834!24516231     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nephrol+Dial+Transplant 2014 ; 29 (4): 864-72 Nephropedia Template TP {{tp|p=24516231|t=2014. DNA methylation profile associated with rapid decline in kidney function: findings from the CRIC Study |pdf=|usr=}}{{24516231}} gab.com Text DNA methylation profile associated with rapid decline in kidney function: findings from the CRIC Study JO: Nephrol Dial Transplant http://www.kidney.de/pget.php?&tw=1&pmid=24516231 #FOAvip Background: Epigenetic mechanisms may be important in the progression of chronic kidney disease (CKD). Methods: We studied the genome-wide DNA methylation pattern associated with rapid loss of kidney function using the Infinium HumanMethylation 450 K BeadChip in 40 Chronic Renal Insufficiency (CRIC) study participants (n = 3939) with the highest and lowest rates of decline in estimated glomerular filtration rate. Results: The mean eGFR slope was 2.2 (1.4) and ?5.1 (1.2) mL/min/1.73 m2 in the stable kidney function group and the rapid progression group, respectively. CpG islands in NPHP4, IQSEC1 and TCF3 were hypermethylated to a larger extent in subjects with stable kidney function (P-values of 7.8E?05 to 9.5E?05). These genes are involved in pathways known to promote the epithelial to mesenchymal transition and renal fibrosis. Other CKD-related genes that were differentially methylated are NOS3, NFKBIL2, CLU, NFKBIB, TGFB3 and TGFBI, which are involved in oxidative stress and inflammatory pathways (P-values of 4.5E?03 to 0.046). Pathway analysis using Ingenuity Pathway Analysis showed that gene networks related to cell signaling, carbohydrate metabolism and human behavior are epigenetically regulated in CKD. Conclusions: Epigenetic modifications may be important in determining the rate of loss of kidney function in patients with established CKD. Twit Text FOAVip DNA methylation profile associated with rapid decline in kidney function: findings from the CRIC Study ????Nephrol Dial Transplant http://www.kidney.de/pget.php?&tw=1&pmid=24516231 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24516231 #FOAvip English Wikipedia <ref>{{Cite pmid|24516231}}</ref> DNA methylation profile associated with rapid decline in kidney function: findings from the CRIC Study #MMPMID24516231 Wing MR; Devaney JM; Joffe MM; Xie D; Feldman HI; Dominic EA; Guzman NJ; Ramezani A; Susztak K; Herman JG; Cope L; Harmon B; Kwabi-Addo B; Gordish-Dressman H; Go AS; He J; Lash JP; Kusek JW; Raj DS Nephrol Dial Transplant 2014[Apr]; 29 (4): 864-72 PMID24516231show ga Background: Epigenetic mechanisms may be important in the progression of chronic kidney disease (CKD). Methods: We studied the genome-wide DNA methylation pattern associated with rapid loss of kidney function using the Infinium HumanMethylation 450 K BeadChip in 40 Chronic Renal Insufficiency (CRIC) study participants (n = 3939) with the highest and lowest rates of decline in estimated glomerular filtration rate. Results: The mean eGFR slope was 2.2 (1.4) and ?5.1 (1.2) mL/min/1.73 m2 in the stable kidney function group and the rapid progression group, respectively. CpG islands in NPHP4, IQSEC1 and TCF3 were hypermethylated to a larger extent in subjects with stable kidney function (P-values of 7.8E?05 to 9.5E?05). These genes are involved in pathways known to promote the epithelial to mesenchymal transition and renal fibrosis. Other CKD-related genes that were differentially methylated are NOS3, NFKBIL2, CLU, NFKBIB, TGFB3 and TGFBI, which are involved in oxidative stress and inflammatory pathways (P-values of 4.5E?03 to 0.046). Pathway analysis using Ingenuity Pathway Analysis showed that gene networks related to cell signaling, carbohydrate metabolism and human behavior are epigenetically regulated in CKD. Conclusions: Epigenetic modifications may be important in determining the rate of loss of kidney function in patients with established CKD. äDNA methylation profile associated with rapid decline in kidney functi(epmc).pdf DeepDyve Pubget Overpricing