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Inhibitory Fc? receptor is required for the maintenance of tolerance through
distinct mechanisms
#MMPMID24563255
Li F
; Smith P
; Ravetch JV
J Immunol
2014[Apr]; 192
(7
): 3021-8
PMID24563255
show ga
The inhibitory Fc?R Fc?RIIB is widely expressed on B cells, dendritic cells
(DCs), and myeloid effector cells and modulates a variety of Ab-driven in vivo
functions. Although it has been established that Fc?RIIB plays an important role
in the maintenance of peripheral tolerance, the responsible cell-specific Fc?RIIB
expression remains to be determined. In this study, we generated mice with
selective deletion of Fc?RIIB in B cells, DCs, and myeloid effector cells and
evaluated these novel strains in models of tolerance and autoimmune diseases. Our
results demonstrate that mice with selective deletion of Fc?RIIB expression in B
cells and DCs have increased Ab and T cell responses, respectively, and display
enhanced susceptibility to disease in distinct models, suggesting that Fc?RIIB
expression in distinct cellular populations contributes to the maintenance of
peripheral tolerance through different mechanisms.
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