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10.1007/s40620-014-0055-2 http://scihub22266oqcxt.onion/10.1007/s40620-014-0055-2 C3965190!3965190!24510764     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Nephrol 2014 ; 27 (2): 151-7 Nephropedia Template TP {{tp|p=24510764|t=2014. Netrin-1, a urinary proximal tubular injury marker, is elevated early in the time course of human diabetes |pdf=|usr=}}{{24510764}} gab.com Text Netrin-1, a urinary proximal tubular injury marker, is elevated early in the time course of human diabetes JO: J Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=24510764 #FOAvip Background: Netrin-1 was recently identified as an early diagnostic biomarker of chronic kidney disease (CKD) in an experimental animal model. However, its usefulness for early diagnosis of CKD in humans is unknown. The current study evaluated whether netrin-1 is increased in urine from human diabetic patients. Methods: Spot urine samples from healthy volunteers, diabetes without microalbuminuria, diabetes with microalbuminuria and diabetes with macroalbuminuria were collected after receiving consent. Netrin-1 in urine was quantified by enzyme-linked immunosorbent assay (ELISA) and the data analyzed to determine whether urinary netrin-1 significantly correlates with disease progression Results: Urinary netrin-1 levels were significantly increased in normoalbuminuric diabetic patients compared to healthy controls, and still further elevated in patients with microalbuminuria and overt nephropathy. Urinary netrin-1 was significantly associated with albuminuria and estimated glomerular filtration rate (eGFR), independently of age and sex. Conclusion: Netrin-1 is detectable in urine from diabetic patients and may serve as a useful early diagnostic biomarker predicting the development of CKD in diabetes. Twit Text FOAVip Netrin-1, a urinary proximal tubular injury marker, is elevated early in the time course of human diabetes ????J Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=24510764 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24510764 #FOAvip English Wikipedia <ref>{{Cite pmid|24510764}}</ref> Netrin-1, a urinary proximal tubular injury marker, is elevated early in the time course of human diabetes #MMPMID24510764 Jayakumar C; Nauta FL; Bakker SJ; Bilo H; Gansevoort RT; Johnson MH; Ramesh G J Nephrol 2014[Apr]; 27 (2): 151-7 PMID24510764show ga Background: Netrin-1 was recently identified as an early diagnostic biomarker of chronic kidney disease (CKD) in an experimental animal model. However, its usefulness for early diagnosis of CKD in humans is unknown. The current study evaluated whether netrin-1 is increased in urine from human diabetic patients. Methods: Spot urine samples from healthy volunteers, diabetes without microalbuminuria, diabetes with microalbuminuria and diabetes with macroalbuminuria were collected after receiving consent. Netrin-1 in urine was quantified by enzyme-linked immunosorbent assay (ELISA) and the data analyzed to determine whether urinary netrin-1 significantly correlates with disease progression Results: Urinary netrin-1 levels were significantly increased in normoalbuminuric diabetic patients compared to healthy controls, and still further elevated in patients with microalbuminuria and overt nephropathy. Urinary netrin-1 was significantly associated with albuminuria and estimated glomerular filtration rate (eGFR), independently of age and sex. Conclusion: Netrin-1 is detectable in urine from diabetic patients and may serve as a useful early diagnostic biomarker predicting the development of CKD in diabetes. äNetrin-1, a urinary proximal tubular injury marker, is elevated early (epmc).pdf DeepDyve Pubget Overpricing