Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24510764
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Nephrol
2014 ; 27
(2
): 151-7
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Netrin-1, a urinary proximal tubular injury marker, is elevated early in the time
course of human diabetes
#MMPMID24510764
Jayakumar C
; Nauta FL
; Bakker SJ
; Bilo H
; Gansevoort RT
; Johnson MH
; Ramesh G
J Nephrol
2014[Apr]; 27
(2
): 151-7
PMID24510764
show ga
BACKGROUND: Netrin-1 was recently identified as an early diagnostic biomarker of
chronic kidney disease (CKD) in an experimental animal model. However, its
usefulness for early diagnosis of CKD in humans is unknown. The current study
evaluated whether netrin-1 is increased in urine from human diabetic patients.
METHODS: Spot urine samples from healthy volunteers, diabetes without
microalbuminuria, diabetes with microalbuminuria and diabetes with
macroalbuminuria were collected after receiving consent. Netrin-1 in urine was
quantified by enzyme-linked immunosorbent assay and the data analyzed to
determine whether urinary netrin-1 significantly correlates with disease
progression. RESULTS: Urinary netrin-1 levels were significantly increased in
normoalbuminuric diabetic patients compared to healthy controls, and still
further elevated in patients with microalbuminuria and overt nephropathy. Urinary
netrin-1 was significantly associated with albuminuria and estimated glomerular
filtration rate, independently of age and sex. CONCLUSION: Netrin-1 is detectable
in urine from diabetic patients and may serve as a useful early diagnostic
biomarker predicting the development of CKD in diabetes.