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10.2337/db13-1139 http://scihub22266oqcxt.onion/10.2337/db13-1139 C3964504!3964504 !24379350     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24379350 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Diabetes 2014 ; 63 (4 ): 1340-52 Nephropedia Template TP {{tp|p=24379350 |t=2014. Otopetrin 1 protects mice from obesity-associated metabolic dysfunction through attenuating adipose tissue inflammation |pdf=|usr=}}{{24379350 }} gab.com Text Otopetrin 1 protects mice from obesity-associated metabolic dysfunction through attenuating adipose tissue inflammation JO: Diabetes http://www.kidney.de/pget.php?&tw=1&pmid=24379350 #FOAvip Chronic low-grade inflammation is emerging as a pathogenic link between obesity and metabolic disease. Persistent immune activation in white adipose tissue (WAT) impairs insulin sensitivity and systemic metabolism, in part, through the actions of proinflammatory cytokines. Whether obesity engages an adaptive mechanism to counteract chronic inflammation in adipose tissues has not been elucidated. Here we identified otopetrin 1 (Otop1) as a component of a counterinflammatory pathway that is induced in WAT during obesity. Otop1 expression is markedly increased in obese mouse WAT and is stimulated by tumor necrosis factor-? in cultured adipocytes. Otop1 mutant mice respond to high-fat diet with pronounced insulin resistance and hepatic steatosis, accompanied by augmented adipose tissue inflammation. Otop1 attenuates interferon-? (IFN-?) signaling in adipocytes through selective downregulation of the transcription factor STAT1. Using a tagged vector, we found that Otop1 physically interacts with endogenous STAT1. Thus, Otop1 defines a unique target of cytokine signaling that attenuates obesity-induced adipose tissue inflammation and plays an adaptive role in maintaining metabolic homeostasis in obesity. Twit Text FOAVip Otopetrin 1 protects mice from obesity-associated metabolic dysfunction through attenuating adipose tissue inflammation ????Diabetes http://www.kidney.de/pget.php?&tw=1&pmid=24379350 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24379350 #FOAvip English Wikipedia <ref>{{Cite pmid|24379350 }}</ref> Otopetrin 1 protects mice from obesity-associated metabolic dysfunction through attenuating adipose tissue inflammation #MMPMID24379350 Wang GX ; Cho KW ; Uhm M ; Hu CR ; Li S ; Cozacov Z ; Xu AE ; Cheng JX ; Saltiel AR ; Lumeng CN ; Lin JD Diabetes 2014[Apr]; 63 (4 ): 1340-52 PMID24379350 show ga Chronic low-grade inflammation is emerging as a pathogenic link between obesity and metabolic disease. Persistent immune activation in white adipose tissue (WAT) impairs insulin sensitivity and systemic metabolism, in part, through the actions of proinflammatory cytokines. Whether obesity engages an adaptive mechanism to counteract chronic inflammation in adipose tissues has not been elucidated. Here we identified otopetrin 1 (Otop1) as a component of a counterinflammatory pathway that is induced in WAT during obesity. Otop1 expression is markedly increased in obese mouse WAT and is stimulated by tumor necrosis factor-? in cultured adipocytes. Otop1 mutant mice respond to high-fat diet with pronounced insulin resistance and hepatic steatosis, accompanied by augmented adipose tissue inflammation. Otop1 attenuates interferon-? (IFN-?) signaling in adipocytes through selective downregulation of the transcription factor STAT1. Using a tagged vector, we found that Otop1 physically interacts with endogenous STAT1. Thus, Otop1 defines a unique target of cytokine signaling that attenuates obesity-induced adipose tissue inflammation and plays an adaptive role in maintaining metabolic homeostasis in obesity. |Adipose Tissue, White/metabolism [MESH] |Adipose Tissue/*pathology [MESH] |Animals [MESH] |Diet, High-Fat [MESH] |Homeostasis/drug effects [MESH] |Inflammation/immunology/*prevention & control [MESH] |Insulin Resistance/physiology [MESH] |Interferon-gamma/drug effects [MESH] |Male [MESH] |Membrane Proteins/metabolism/*pharmacology [MESH] |Mice [MESH] |Obesity/*metabolism [MESH]Otopetrin 1 protects mice from obesity-associated metabolic dysfunctio(epmc).pdf DeepDyve Pubget Overpricing