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10.1152/ajprenal.00656.2013 http://scihub22266oqcxt.onion/10.1152/ajprenal.00656.2013 C3962601!3962601!24477683     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Physiol+Renal+Physiol 2014 ; 306 (7): F701-9 Nephropedia Template TP {{tp|p=24477683|t=2014. Regulation of nephron water and electrolyte transport by adenylyl cyclases |pdf=|usr=}}{{24477683}} gab.com Text Regulation of nephron water and electrolyte transport by adenylyl cyclases JO: Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=24477683 #FOAvip Adenylyl cyclases (AC) catalyze formation of cAMP, a critical component of G protein-coupled receptor signaling. So far, nine distinct membrane-bound AC isoforms (AC1-9) and one soluble AC (sAC) have been identified and, except for AC8, all of them are expressed in the kidney. While the role of ACs in renal cAMP formation is well established, we are just beginning to understand the function of individual AC isoforms, particularly with regard to hormonal regulation of transporter and channel phosphorylation, membrane abundance, and trafficking. This review focuses on the role of different AC isoforms in regulating renal water and electrolyte transport in health as well as potential pathological implications of disordered AC isoform function. In particular, we focus on modulation of transporter and channel abundance, activity, and phosphorylation, with an emphasis on studies employing genetically modified animals. As will be described, it is now evident that specific AC isoforms can exert unique effects in the kidney that may have important implications in our understanding of normal physiology as well as disease pathogenesis. Twit Text FOAVip Regulation of nephron water and electrolyte transport by adenylyl cyclases ????Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=24477683 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24477683 #FOAvip English Wikipedia <ref>{{Cite pmid|24477683}}</ref> Regulation of nephron water and electrolyte transport by adenylyl cyclases #MMPMID24477683 Rieg T; Kohan DE Am J Physiol Renal Physiol 2014[Apr]; 306 (7): F701-9 PMID24477683show ga Adenylyl cyclases (AC) catalyze formation of cAMP, a critical component of G protein-coupled receptor signaling. So far, nine distinct membrane-bound AC isoforms (AC1-9) and one soluble AC (sAC) have been identified and, except for AC8, all of them are expressed in the kidney. While the role of ACs in renal cAMP formation is well established, we are just beginning to understand the function of individual AC isoforms, particularly with regard to hormonal regulation of transporter and channel phosphorylation, membrane abundance, and trafficking. This review focuses on the role of different AC isoforms in regulating renal water and electrolyte transport in health as well as potential pathological implications of disordered AC isoform function. In particular, we focus on modulation of transporter and channel abundance, activity, and phosphorylation, with an emphasis on studies employing genetically modified animals. As will be described, it is now evident that specific AC isoforms can exert unique effects in the kidney that may have important implications in our understanding of normal physiology as well as disease pathogenesis. äRegulation of nephron water and electrolyte transport by adenylyl cycl(epmc).pdf DeepDyve Pubget Overpricing