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2014 ; 20
(11
): 1827-50
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Role of heme oxygenase-1 in postnatal differentiation of stem cells: a possible
cross-talk with microRNAs
#MMPMID24053682
Kozakowska M
; Szade K
; Dulak J
; Jozkowicz A
Antioxid Redox Signal
2014[Apr]; 20
(11
): 1827-50
PMID24053682
show ga
SIGNIFICANCE: Heme oxygenase-1 (HO-1) converts heme to biliverdin, carbon
monoxide, and ferrous ions, but its cellular functions are far beyond heme
metabolism. HO-1 via heme removal and degradation products acts as a
cytoprotective, anti-inflammatory, immunomodulatory, and proangiogenic protein,
regulating also a cell cycle. Additionally, HO-1 can translocate to nucleus and
regulate transcription factors, so it can also act independently of enzymatic
function. RECENT ADVANCES: Recently, a body of evidence has emerged indicating a
role for HO-1 in postnatal differentiation of stem and progenitor cells.
Maturation of satellite cells, skeletal myoblasts, adipocytes, and osteoclasts is
inhibited by HO-1, whereas neurogenic differentiation and formation of
cardiomyocytes perhaps can be enhanced. Moreover, HO-1 influences a lineage
commitment in pluripotent stem cells and maturation of hematopoietic cells. It
may play a role in development of osteoblasts, but descriptions of its exact
effects are inconsistent. CRITICAL ISSUES: In this review we discuss a role of
HO-1 in cell differentiation, and possible HO-1-dependent signal transduction
pathways. Among the potential mediators, we focused on microRNA (miRNA). These
small, noncoding RNAs are critical for cell differentiation. Recently we have
found that HO-1 not only influences expression of specific miRNAs but also
regulates miRNA processing enzymes. FUTURE DIRECTIONS: It seems that interplay
between HO-1 and miRNAs may be important in regulating fates of stem and
progenitor cells and needs further intensive studies.
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