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10.1513/AnnalsATS.201211-107OC http://scihub22266oqcxt.onion/10.1513/AnnalsATS.201211-107OC C3960905!3960905!23802813     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Ann+Am+Thorac+Soc 2013 ; 10 (3): 179-87 Nephropedia Template TP {{tp|p=23802813|t=2013. Changes in Cystic Fibrosis Airway Microbiota at Pulmonary Exacerbation |pdf=|usr=}}{{23802813}} gab.com Text Changes in Cystic Fibrosis Airway Microbiota at Pulmonary Exacerbation JO: Ann Am Thorac Soc http://www.kidney.de/pget.php?&tw=1&pmid=23802813 #FOAvip Rationale: In persons with cystic fibrosis (CF), repeated exacerbations of pulmonary symptoms are associated with a progressive decline in lung function. Changes in the airway microbiota around the time of exacerbations are not well understood.Objectives: To characterize changes in airway bacterial communities around the time of exacerbations and to identify predictors for these changes.Methods: DNA prepared from 68 paired baseline and exacerbation sputum samples collected from 28 patients with CF were subjected to barcoded 16S rRNA gene pyrosequencing. Bacterial density was calculated by quantitative PCR.Measurements and Main Results: Overall, significant differences in bacterial community diversity and bacterial density between baseline and exacerbation samples were not observed. However, considerable changes in community structures were observed in a subset of patients. In these patients, the dominant taxa and initial level of community diversity were significant predictors of the magnitude of community structure changes at exacerbation. Pseudomonas-dominant communities became more diverse at exacerbation compared with communities with other or no dominant species. The relative abundance of Gemella increased in 24 (83%) of 29 samples at exacerbation and was found to be the most discriminative genus between baseline and exacerbation samples.Conclusions: The magnitude of changes in the CF lung microbiota around the time of exacerbation was found to be largely dependent on community diversity and composition at baseline. Certain genera appear to play important roles in driving change in airway bacterial community composition at exacerbation. Gemella might play a direct role in and/or be a biomarker for pulmonary exacerbation. Twit Text FOAVip Changes in Cystic Fibrosis Airway Microbiota at Pulmonary Exacerbation ????Ann Am Thorac Soc http://www.kidney.de/pget.php?&tw=1&pmid=23802813 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23802813 #FOAvip English Wikipedia <ref>{{Cite pmid|23802813}}</ref> Changes in Cystic Fibrosis Airway Microbiota at Pulmonary Exacerbation #MMPMID23802813 Carmody LA; Zhao J; Schloss PD; Petrosino JF; Murray S; Young VB; Li JZ; LiPuma JJ Ann Am Thorac Soc 2013[Jun]; 10 (3): 179-87 PMID23802813show ga Rationale: In persons with cystic fibrosis (CF), repeated exacerbations of pulmonary symptoms are associated with a progressive decline in lung function. Changes in the airway microbiota around the time of exacerbations are not well understood.Objectives: To characterize changes in airway bacterial communities around the time of exacerbations and to identify predictors for these changes.Methods: DNA prepared from 68 paired baseline and exacerbation sputum samples collected from 28 patients with CF were subjected to barcoded 16S rRNA gene pyrosequencing. Bacterial density was calculated by quantitative PCR.Measurements and Main Results: Overall, significant differences in bacterial community diversity and bacterial density between baseline and exacerbation samples were not observed. However, considerable changes in community structures were observed in a subset of patients. In these patients, the dominant taxa and initial level of community diversity were significant predictors of the magnitude of community structure changes at exacerbation. Pseudomonas-dominant communities became more diverse at exacerbation compared with communities with other or no dominant species. The relative abundance of Gemella increased in 24 (83%) of 29 samples at exacerbation and was found to be the most discriminative genus between baseline and exacerbation samples.Conclusions: The magnitude of changes in the CF lung microbiota around the time of exacerbation was found to be largely dependent on community diversity and composition at baseline. Certain genera appear to play important roles in driving change in airway bacterial community composition at exacerbation. Gemella might play a direct role in and/or be a biomarker for pulmonary exacerbation. äChanges in Cystic Fibrosis Airway Microbiota at Pulmonary Exacerbation(epmc).pdf DeepDyve Pubget Overpricing