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10.1016/j.nlm.2013.09.009 http://scihub22266oqcxt.onion/10.1016/j.nlm.2013.09.009 C3960373!3960373 !24055595     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24055595 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Neurobiol+Learn+Mem 2014 ; 113 (ä): 125-34 Nephropedia Template TP {{tp|p=24055595 |t=2014. Cannabinoid modulation of prefrontal-limbic activation during fear extinction learning and recall in humans |pdf=|usr=}}{{24055595 }} gab.com Text Cannabinoid modulation of prefrontal-limbic activation during fear extinction learning and recall in humans JO: Neurobiol Learn Mem http://www.kidney.de/pget.php?&tw=1&pmid=24055595 #FOAvip Pre-extinction administration of ?9-tetrahydrocannibinol (THC) facilitates recall of extinction in healthy humans, and evidence from animal studies suggest that this likely occurs via enhancement of the cannabinoid system within the ventromedial prefrontal cortex (vmPFC) and hippocampus (HIPP), brain structures critical to fear extinction. However, the effect of cannabinoids on the underlying neural circuitry of extinction memory recall in humans has not been demonstrated. We conducted a functional magnetic resonance imaging (fMRI) study using a randomized, double-blind, placebo-controlled, between-subjects design (N=14/group) coupled with a standard Pavlovian fear extinction paradigm and an acute pharmacological challenge with oral dronabinol (synthetic THC) in healthy adult volunteers. We examined the effects of THC on vmPFC and HIPP activation when tested for recall of extinction learning 24 h after extinction learning. Compared to subjects who received placebo, participants who received THC showed increased vmPFC and HIPP activation to a previously extinguished conditioned stimulus (CS+E) during extinction memory recall. This study provides the first evidence that pre-extinction administration of THC modulates prefrontal-limbic circuits during fear extinction in humans and prompts future investigation to test if cannabinoid agonists can rescue or correct the impaired behavioral and neural function during extinction recall in patients with PTSD. Ultimately, the cannabinoid system may serve as a promising target for innovative intervention strategies (e.g. pharmacological enhancement of exposure-based therapy) in PTSD and other fear learning-related disorders. Twit Text FOAVip Cannabinoid modulation of prefrontal-limbic activation during fear extinction learning and recall in humans ????Neurobiol Learn Mem http://www.kidney.de/pget.php?&tw=1&pmid=24055595 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24055595 #FOAvip English Wikipedia <ref>{{Cite pmid|24055595 }}</ref> Cannabinoid modulation of prefrontal-limbic activation during fear extinction learning and recall in humans #MMPMID24055595 Rabinak CA ; Angstadt M ; Lyons M ; Mori S ; Milad MR ; Liberzon I ; Phan KL Neurobiol Learn Mem 2014[Sep]; 113 (ä): 125-34 PMID24055595 show ga Pre-extinction administration of ?9-tetrahydrocannibinol (THC) facilitates recall of extinction in healthy humans, and evidence from animal studies suggest that this likely occurs via enhancement of the cannabinoid system within the ventromedial prefrontal cortex (vmPFC) and hippocampus (HIPP), brain structures critical to fear extinction. However, the effect of cannabinoids on the underlying neural circuitry of extinction memory recall in humans has not been demonstrated. We conducted a functional magnetic resonance imaging (fMRI) study using a randomized, double-blind, placebo-controlled, between-subjects design (N=14/group) coupled with a standard Pavlovian fear extinction paradigm and an acute pharmacological challenge with oral dronabinol (synthetic THC) in healthy adult volunteers. We examined the effects of THC on vmPFC and HIPP activation when tested for recall of extinction learning 24 h after extinction learning. Compared to subjects who received placebo, participants who received THC showed increased vmPFC and HIPP activation to a previously extinguished conditioned stimulus (CS+E) during extinction memory recall. This study provides the first evidence that pre-extinction administration of THC modulates prefrontal-limbic circuits during fear extinction in humans and prompts future investigation to test if cannabinoid agonists can rescue or correct the impaired behavioral and neural function during extinction recall in patients with PTSD. Ultimately, the cannabinoid system may serve as a promising target for innovative intervention strategies (e.g. pharmacological enhancement of exposure-based therapy) in PTSD and other fear learning-related disorders. |Adult [MESH] |Cannabinoid Receptor Agonists/administration & dosage/*pharmacology [MESH] |Conditioning, Classical/physiology [MESH] |Double-Blind Method [MESH] |Dronabinol/administration & dosage/pharmacology [MESH] |Extinction, Psychological/drug effects/*physiology [MESH] |Fear/drug effects/*physiology [MESH] |Female [MESH] |Functional Neuroimaging [MESH] |Humans [MESH] |Limbic System/drug effects/*physiology [MESH] |Magnetic Resonance Imaging [MESH] |Male [MESH] |Mental Recall/drug effects/*physiology [MESH] |Placebos [MESH] |Prefrontal Cortex/drug effects/*physiology [MESH]Cannabinoid modulation of prefrontal-limbic activation during fear ext(epmc).pdf DeepDyve Pubget Overpricing