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10.1242/dev.104539 http://scihub22266oqcxt.onion/10.1242/dev.104539 C3957370!3957370 !24598168     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24598168 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Development 2014 ; 141 (7 ): 1465-72 Nephropedia Template TP {{tp|p=24598168 |t=2014. Dynamin 2 regulation of integrin endocytosis, but not VEGF signaling, is crucial for developmental angiogenesis |pdf=|usr=}}{{24598168 }} gab.com Text Dynamin 2 regulation of integrin endocytosis, but not VEGF signaling, is crucial for developmental angiogenesis JO: Development http://www.kidney.de/pget.php?&tw=1&pmid=24598168 #FOAvip Here we show that dynamin 2 (Dnm2) is essential for angiogenesis in vitro and in vivo. In cultured endothelial cells lacking Dnm2, vascular endothelial growth factor (VEGF) signaling and receptor levels are augmented whereas cell migration and morphogenesis are impaired. Mechanistically, the loss of Dnm2 increases focal adhesion size and the surface levels of multiple integrins and reduces the activation state of ?1 integrin. In vivo, the constitutive or inducible loss of Dnm2 in endothelium impairs branching morphogenesis and promotes the accumulation of ?1 integrin at sites of failed angiogenic sprouting. Collectively, our data show that Dnm2 uncouples VEGF signaling from function and coordinates the endocytic turnover of integrins in a manner that is crucially important for angiogenesis in vitro and in vivo. Twit Text FOAVip Dynamin 2 regulation of integrin endocytosis, but not VEGF signaling, is crucial for developmental angiogenesis ????Development http://www.kidney.de/pget.php?&tw=1&pmid=24598168 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24598168 #FOAvip English Wikipedia <ref>{{Cite pmid|24598168 }}</ref> Dynamin 2 regulation of integrin endocytosis, but not VEGF signaling, is crucial for developmental angiogenesis #MMPMID24598168 Lee MY ; Skoura A ; Park EJ ; Landskroner-Eiger S ; Jozsef L ; Luciano AK ; Murata T ; Pasula S ; Dong Y ; Bouaouina M ; Calderwood DA ; Ferguson SM ; De Camilli P ; Sessa WC Development 2014[Apr]; 141 (7 ): 1465-72 PMID24598168 show ga Here we show that dynamin 2 (Dnm2) is essential for angiogenesis in vitro and in vivo. In cultured endothelial cells lacking Dnm2, vascular endothelial growth factor (VEGF) signaling and receptor levels are augmented whereas cell migration and morphogenesis are impaired. Mechanistically, the loss of Dnm2 increases focal adhesion size and the surface levels of multiple integrins and reduces the activation state of ?1 integrin. In vivo, the constitutive or inducible loss of Dnm2 in endothelium impairs branching morphogenesis and promotes the accumulation of ?1 integrin at sites of failed angiogenic sprouting. Collectively, our data show that Dnm2 uncouples VEGF signaling from function and coordinates the endocytic turnover of integrins in a manner that is crucially important for angiogenesis in vitro and in vivo. |Animals [MESH] |Animals, Newborn [MESH] |Blood Vessels/*embryology/growth & development [MESH] |Cells, Cultured [MESH] |Dynamin II/genetics/*physiology [MESH] |Embryo, Mammalian [MESH] |Endocytosis/*genetics [MESH] |Female [MESH] |Human Umbilical Vein Endothelial Cells/physiology [MESH] |Humans [MESH] |Integrins/*metabolism [MESH] |Male [MESH] |Mice [MESH] |Mice, Transgenic [MESH] |Neovascularization, Physiologic/*genetics [MESH] |Signal Transduction/physiology [MESH]Dynamin 2 regulation of integrin endocytosis, but not VEGF signaling, (epmc).pdf DeepDyve Pubget Overpricing