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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Proc+Natl+Acad+Sci+U+S+A 2014 ; 111 (10): 3793-8 Nephropedia Template TP
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Toll-like receptor 10 is involved in induction of innate immune responses to influenza virus infection #MMPMID24567377
Lee SMY; Kok KH; Jaume M; Cheung TKW; Yip TF; Lai JCC; Guan Y; Webster RG; Jin DY; Peiris JSM
Proc Natl Acad Sci U S A 2014[Mar]; 111 (10): 3793-8 PMID24567377show ga
Toll-like receptors (TLRs) play key roles in innate immune recognition of pathogens leading to the activation of innate host defenses and sometimes to immunopathology. In humans, there are 10 identified TLR members, designated TLRs 1?10. Of those, TLR10 remains the only one without a defined ligand or function. We now provide previously unidentified evidence that TLR10 plays a role in innate immune responses following influenza viral infection. Influenza viruses are subtyped on the hemagglutinin (H) and neuraminidase (N) proteins. Compared with seasonal influenza virus H1N1, the highly pathogenic avian influenza virus H5N1 is a more potent inducer of TLR10 expression. Given the importance of innate immune sensing receptors in host defense and pathogenesis, evidence of a functional role for TLR10 in influenza infection suggests that this receptor probably plays a role in a range of other viral and perhaps other microbial diseases.