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10.1073/pnas.1324266111 http://scihub22266oqcxt.onion/10.1073/pnas.1324266111 C3956146!3956146 !24567377     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24567377 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2014 ; 111 (10 ): 3793-8 Nephropedia Template TP {{tp|p=24567377 |t=2014. Toll-like receptor 10 is involved in induction of innate immune responses to influenza virus infection |pdf=|usr=}}{{24567377 }} gab.com Text Toll-like receptor 10 is involved in induction of innate immune responses to influenza virus infection JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=24567377 #FOAvip Toll-like receptors (TLRs) play key roles in innate immune recognition of pathogen-associated molecular patterns of invading microbes. Among the 10 TLR family members identified in humans, TLR10 remains an orphan receptor without known agonist or function. TLR10 is a pseudogene in mice and mouse models are noninformative in this regard. Using influenza virus infection in primary human peripheral blood monocyte-derived macrophages and a human monocytic cell line, we now provide previously unidentified evidence that TLR10 plays a role in innate immune responses following viral infection. Influenza virus infection increased TLR10 expression and TLR10 contributed to innate immune sensing of viral infection leading to cytokine induction, including proinflammatory cytokines and interferons. TLR10 induction is more pronounced following infection with highly pathogenic avian influenza H5N1 virus compared with a low pathogenic H1N1 virus. Induction of TLR10 by virus infection requires active virus replication and de novo protein synthesis. Culture supernatants of virus-infected cells modestly up-regulate TLR10 expression in nonvirus-infected cells. Signaling via TLR10 was activated by the functional RNA-protein complex of influenza virus leading to robust induction of cytokine expression. Taken together, our findings identify TLR10 as an important innate immune sensor of viral infection and its role in innate immune defense and immunopathology following viral and bacterial pathogens deserves attention. Twit Text FOAVip Toll-like receptor 10 is involved in induction of innate immune responses to influenza virus infection ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=24567377 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24567377 #FOAvip English Wikipedia <ref>{{Cite pmid|24567377 }}</ref> Toll-like receptor 10 is involved in induction of innate immune responses to influenza virus infection #MMPMID24567377 Lee SM ; Kok KH ; Jaume M ; Cheung TK ; Yip TF ; Lai JC ; Guan Y ; Webster RG ; Jin DY ; Peiris JS Proc Natl Acad Sci U S A 2014[Mar]; 111 (10 ): 3793-8 PMID24567377 show ga Toll-like receptors (TLRs) play key roles in innate immune recognition of pathogen-associated molecular patterns of invading microbes. Among the 10 TLR family members identified in humans, TLR10 remains an orphan receptor without known agonist or function. TLR10 is a pseudogene in mice and mouse models are noninformative in this regard. Using influenza virus infection in primary human peripheral blood monocyte-derived macrophages and a human monocytic cell line, we now provide previously unidentified evidence that TLR10 plays a role in innate immune responses following viral infection. Influenza virus infection increased TLR10 expression and TLR10 contributed to innate immune sensing of viral infection leading to cytokine induction, including proinflammatory cytokines and interferons. TLR10 induction is more pronounced following infection with highly pathogenic avian influenza H5N1 virus compared with a low pathogenic H1N1 virus. Induction of TLR10 by virus infection requires active virus replication and de novo protein synthesis. Culture supernatants of virus-infected cells modestly up-regulate TLR10 expression in nonvirus-infected cells. Signaling via TLR10 was activated by the functional RNA-protein complex of influenza virus leading to robust induction of cytokine expression. Taken together, our findings identify TLR10 as an important innate immune sensor of viral infection and its role in innate immune defense and immunopathology following viral and bacterial pathogens deserves attention. |Animals [MESH] |Benzothiazoles [MESH] |Blotting, Western [MESH] |DNA Primers/genetics [MESH] |Diamines [MESH] |Dogs [MESH] |Enzyme-Linked Immunosorbent Assay [MESH] |Fluorescent Antibody Technique [MESH] |Humans [MESH] |Immunity, Innate/*immunology [MESH] |Influenza A Virus, H1N1 Subtype/immunology [MESH] |Influenza A Virus, H5N1 Subtype/*immunology [MESH] |Influenza, Human/*immunology [MESH] |Macrophages [MESH] |Madin Darby Canine Kidney Cells [MESH] |Mice [MESH] |Organic Chemicals [MESH] |Quinolines [MESH] |RNA, Small Interfering/genetics [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH]Toll-like receptor 10 is involved in induction of innate immune respon(epmc).pdf DeepDyve Pubget Overpricing