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Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Am+J+Public+Health 2014 ; 104 (3): 474-81 Nephropedia Template TP
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Previous Exposure to HCV Among Persons Born During 1945?1965: Prevalence and Predictors, United States, 1999?2008 #MMPMID24432883
Am J Public Health 2014[Mar]; 104 (3): 474-81 PMID24432883show ga
Objectives. We examined HCV exposure prevalence and predictors among persons in the United States born during 1945?1965.Methods. With data from the 1999?2008 National Health and Nutrition Examination Survey, we calculated the proportion of persons born during 1945?1965 who tested positive for HCV antibody (anti-HCV) and analyzed the prevalence by sociodemographic and behavioral risk factors.Results. Anti-HCV prevalence in the 1945?1965 birth cohort was 3.2% (95% confidence interval [CI]?=?2.8%, 3.8%), substantially higher than among other adults (0.9%). Within the cohort, anti-HCV prevalence was higher among non-Hispanic Blacks (6.4%; 95% CI?=?5.3%, 7.7%), persons with injection drug use histories (56.8%; 95% CI?=?48.4%, 64.8%), and persons with elevated alanine aminotransferase levels (12.7%; 95% CI?=?10.7%, 15.1%). Injection drug use (adjusted odds ratio?=?98.4; 95% CI?=?58.8, 164.5) was the strongest anti-HCV prevalence predictor. Among anti-HCV?positive persons, 57.8% reported having 2 or more alcoholic drinks daily.Conclusions. With the high prevalence of HCV among persons born during 1945?1965, the increasing morbidity and mortality associated with HCV, and reductions in liver cancer and HCV-related mortality when HCV is eradicated, it is critically important to identify persons with HCV and link them to appropriate care.