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10.1038/cdd.2013.188 http://scihub22266oqcxt.onion/10.1038/cdd.2013.188 C3950325!3950325!24413153     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24413153&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Death+Differ 2014 ; 21 (4): 624-33 Nephropedia Template TP {{tp|p=24413153|t=2014. Lats2 is critical for the pluripotency and proper differentiation of stem cells |pdf=|usr=}}{{24413153}} gab.com Text Lats2 is critical for the pluripotency and proper differentiation of stem cells JO: Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=24413153 #FOAvip Differentiation is a highly controlled process essential for embryonic and adult development. Moreover, disruption of proper differentiation is often associated with human diseases, including cancer. We analyzed the involvement of the tumor-suppressor Lats2 in mouse embryonic stem cell (mESC) pluripotency and differentiation, and report that mESCs lacking Lats2 are unable to sustain stemness and are not able to initiate and coordinate developmental transcriptional programs. Lats2?/? mESCs retain bivalent ?poised' chromatin marks on developmental genes and exhibit germ layer ambiguity both in vitro and in vivo. Importantly, in coordinating proper germ layer specification, Lats2 engages in a feedback loop with another tumor suppressor, p53. Twit Text FOAVip Lats2 is critical for the pluripotency and proper differentiation of stem cells ????Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=24413153 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24413153 #FOAvip English Wikipedia <ref>{{Cite pmid|24413153}}</ref> Lats2 is critical for the pluripotency and proper differentiation of stem cells #MMPMID24413153 Aylon Y; Sarver A; Tovy A; Ainbinder E; Oren M Cell Death Differ 2014[Apr]; 21 (4): 624-33 PMID24413153show ga Differentiation is a highly controlled process essential for embryonic and adult development. Moreover, disruption of proper differentiation is often associated with human diseases, including cancer. We analyzed the involvement of the tumor-suppressor Lats2 in mouse embryonic stem cell (mESC) pluripotency and differentiation, and report that mESCs lacking Lats2 are unable to sustain stemness and are not able to initiate and coordinate developmental transcriptional programs. Lats2?/? mESCs retain bivalent ?poised' chromatin marks on developmental genes and exhibit germ layer ambiguity both in vitro and in vivo. Importantly, in coordinating proper germ layer specification, Lats2 engages in a feedback loop with another tumor suppressor, p53. äLats2 is critical for the pluripotency and proper differentiation of s(epmc).pdf DeepDyve Pubget Overpricing