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10.1038/cdd.2013.132 http://scihub22266oqcxt.onion/10.1038/cdd.2013.132 C3950315!3950315!24076587     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Death+Differ 2014 ; 21 (4): 521-32 Nephropedia Template TP {{tp|p=24076587|t=2014. Mapping the p53 transcriptome universe using p53 natural polymorphs |pdf=|usr=}}{{24076587}} gab.com Text Mapping the p53 transcriptome universe using p53 natural polymorphs JO: Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=24076587 #FOAvip The tumor suppressor p53 has defined roles in varied cellular processes including apoptosis and DNA repair. While conventional genomic approaches have suggested a large number of p53 targets, there is a need for a systematic approach to validate these putative genes. We developed a method to identify and validate p53's transcriptional behavior by utilizing 16 non-synonymous p53 single-nucleotide polymorphism (SNP) variants. Five SNPs located within the DNA-binding domain of p53 were found to be functionally null, whereas the other 11 SNPs were p53WT-like in behavior. By integrating p53 ChIP-seq analysis with transcriptome data from the p53 SNP variants, 592 genes were identified as novel p53 targets. Many of these genes mapped to previously less well-characterized aspects of p53 function, such as cell signalling, metabolism, central nervous system, and immune system. These data provide pivotal insights into the involvement of p53 in diverse pathways of normal physiological processes and open new avenues for investigation of p53 function. Twit Text FOAVip Mapping the p53 transcriptome universe using p53 natural polymorphs ????Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=24076587 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24076587 #FOAvip English Wikipedia <ref>{{Cite pmid|24076587}}</ref> Mapping the p53 transcriptome universe using p53 natural polymorphs #MMPMID24076587 Wang B; Niu D; Lam TH; Xiao Z; Ren EC Cell Death Differ 2014[Apr]; 21 (4): 521-32 PMID24076587show ga The tumor suppressor p53 has defined roles in varied cellular processes including apoptosis and DNA repair. While conventional genomic approaches have suggested a large number of p53 targets, there is a need for a systematic approach to validate these putative genes. We developed a method to identify and validate p53's transcriptional behavior by utilizing 16 non-synonymous p53 single-nucleotide polymorphism (SNP) variants. Five SNPs located within the DNA-binding domain of p53 were found to be functionally null, whereas the other 11 SNPs were p53WT-like in behavior. By integrating p53 ChIP-seq analysis with transcriptome data from the p53 SNP variants, 592 genes were identified as novel p53 targets. Many of these genes mapped to previously less well-characterized aspects of p53 function, such as cell signalling, metabolism, central nervous system, and immune system. These data provide pivotal insights into the involvement of p53 in diverse pathways of normal physiological processes and open new avenues for investigation of p53 function. äMapping the p53 transcriptome universe using p53 natural polymorphs (epmc).pdf DeepDyve Pubget Overpricing