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10.1101/cshperspect.a016097 http://scihub22266oqcxt.onion/10.1101/cshperspect.a016097 C3949359!3949359!24591518     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cold+Spring+Harb+Perspect+Biol 2014 ; 6 (3): ä Nephropedia Template TP {{tp|p=24591518|t=2014. The Pre-Endosymbiont Hypothesis: A New Perspective on the Origin and Evolution of Mitochondria |pdf=|usr=}}{{24591518}} gab.com Text The Pre-Endosymbiont Hypothesis: A New Perspective on the Origin and Evolution of Mitochondria JO: Cold Spring Harb Perspect Biol http://www.kidney.de/pget.php?&tw=1&pmid=24591518 #FOAvip Mitochondrial DNA (mtDNA) is unquestionably the remnant of an ?-proteobacterial genome, yet only ?10%?20% of mitochondrial proteins are demonstrably ?-proteobacterial in origin (the ??-proteobacterial component,? or APC). The evolutionary ancestry of the non-?-proteobacterial component (NPC) is obscure and not adequately accounted for in current models of mitochondrial origin. I propose that in the host cell that accommodated an ?-proteobacterial endosymbiont, much of the NPC was already present, in the form of a membrane-bound metabolic organelle (the premitochondrion) that compartmentalized many of the non-energy-generating functions of the contemporary mitochondrion. I suggest that this organelle also possessed a protein import system and various ion and small-molecule transporters. In such a scenario, an ?-proteobacterial endosymbiont could have been converted relatively directly and rapidly into an energy-generating organelle that incorporated the extant metabolic functions of the premitochondrion. This model (the ?pre-endosymbiont hypothesis?) effectively represents a synthesis of previous, contending mitochondrial origin hypotheses, with the bulk of the mitochondrial proteome (much of the NPC) having an endogenous origin and the minority component (the APC) having a xenogenous origin. Twit Text FOAVip The Pre-Endosymbiont Hypothesis: A New Perspective on the Origin and Evolution of Mitochondria ????Cold Spring Harb Perspect Biol http://www.kidney.de/pget.php?&tw=1&pmid=24591518 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24591518 #FOAvip English Wikipedia <ref>{{Cite pmid|24591518}}</ref> The Pre-Endosymbiont Hypothesis: A New Perspective on the Origin and Evolution of Mitochondria #MMPMID24591518 Gray MW Cold Spring Harb Perspect Biol 2014[Mar]; 6 (3): ä PMID24591518show ga Mitochondrial DNA (mtDNA) is unquestionably the remnant of an ?-proteobacterial genome, yet only ?10%?20% of mitochondrial proteins are demonstrably ?-proteobacterial in origin (the ??-proteobacterial component,? or APC). The evolutionary ancestry of the non-?-proteobacterial component (NPC) is obscure and not adequately accounted for in current models of mitochondrial origin. I propose that in the host cell that accommodated an ?-proteobacterial endosymbiont, much of the NPC was already present, in the form of a membrane-bound metabolic organelle (the premitochondrion) that compartmentalized many of the non-energy-generating functions of the contemporary mitochondrion. I suggest that this organelle also possessed a protein import system and various ion and small-molecule transporters. In such a scenario, an ?-proteobacterial endosymbiont could have been converted relatively directly and rapidly into an energy-generating organelle that incorporated the extant metabolic functions of the premitochondrion. This model (the ?pre-endosymbiont hypothesis?) effectively represents a synthesis of previous, contending mitochondrial origin hypotheses, with the bulk of the mitochondrial proteome (much of the NPC) having an endogenous origin and the minority component (the APC) having a xenogenous origin. äThe Pre-Endosymbiont Hypothesis: A New Perspective on the Origin and E(epmc).pdf DeepDyve Pubget Overpricing