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10.1101/cshperspect.a008912 http://scihub22266oqcxt.onion/10.1101/cshperspect.a008912 C3949355!3949355!24591517     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cold+Spring+Harb+Perspect+Biol 2014 ; 6 (3): ä Nephropedia Template TP {{tp|p=24591517|t=2014. Receptor Tyrosine Kinases: Legacy of the First Two Decades |pdf=|usr=}}{{24591517}} gab.com Text Receptor Tyrosine Kinases: Legacy of the First Two Decades JO: Cold Spring Harb Perspect Biol http://www.kidney.de/pget.php?&tw=1&pmid=24591517 #FOAvip Receptor tyrosine kinases (RTKs) and their cellular signaling pathways play important roles in normal development and homeostasis. Aberrations in their activation or signaling leads to many pathologies, especially cancers, motivating the development of a variety of drugs that block RTK signaling that have been successfully applied for the treatment of many cancers. As the current field of RTKs and their signaling pathways are covered by a very large amount of literature, spread over half a century, I am focusing the scope of this review on seminal discoveries made before tyrosine phosphorylation was discovered, and on the early days of research into RTKs and their cellular signaling pathways. I review the history of the early days of research in the field of RTKs. I emphasize key early findings, which provided conceptual frameworks for addressing the questions of how RTKs are activated and how they regulate intracellular signaling pathways. Twit Text FOAVip Receptor Tyrosine Kinases: Legacy of the First Two Decades ????Cold Spring Harb Perspect Biol http://www.kidney.de/pget.php?&tw=1&pmid=24591517 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24591517 #FOAvip English Wikipedia <ref>{{Cite pmid|24591517}}</ref> Receptor Tyrosine Kinases: Legacy of the First Two Decades #MMPMID24591517 Schlessinger J Cold Spring Harb Perspect Biol 2014[Mar]; 6 (3): ä PMID24591517show ga Receptor tyrosine kinases (RTKs) and their cellular signaling pathways play important roles in normal development and homeostasis. Aberrations in their activation or signaling leads to many pathologies, especially cancers, motivating the development of a variety of drugs that block RTK signaling that have been successfully applied for the treatment of many cancers. As the current field of RTKs and their signaling pathways are covered by a very large amount of literature, spread over half a century, I am focusing the scope of this review on seminal discoveries made before tyrosine phosphorylation was discovered, and on the early days of research into RTKs and their cellular signaling pathways. I review the history of the early days of research in the field of RTKs. I emphasize key early findings, which provided conceptual frameworks for addressing the questions of how RTKs are activated and how they regulate intracellular signaling pathways. äReceptor Tyrosine Kinases: Legacy of the First Two Decades (epmc).pdf DeepDyve Pubget Overpricing