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10.1016/j.canlet.2013.12.012

http://scihub22266oqcxt.onion/10.1016/j.canlet.2013.12.012
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C3947657!3947657!24334139
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suck abstract from ncbi


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pmid24334139      Cancer+Lett 2014 ; 346 (1): 63-73
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  • H460 non-small cell lung cancer stem-like holoclones yield tumors with increased vascularity #MMPMID24334139
  • Manley E; Waxman DJ
  • Cancer Lett 2014[Apr]; 346 (1): 63-73 PMID24334139show ga
  • Cancer stem-like cells were isolated from several human tumor cell lines by limiting dilution assays and holoclone morphology, followed by assessment of self-renewal capacity, tumor growth, vascularity, and blood perfusion. H460 holoclone-derived tumors grew slower than parental H460 tumors, but displayed significantly increased microvessel density and tumor blood perfusion. Microarray analysis identified 177 differentially regulated genes in the holoclone-derived tumors, of which 47 were associated with angiogenesis. The dysregulated genes include several small leucine-rich proteoglycans that may modulate angiogenesis and serve as novel therapeutic targets for inhibiting cancer stem cell-driven angiogenesis.
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