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10.1007/s00467-013-2662-x http://scihub22266oqcxt.onion/10.1007/s00467-013-2662-x C3944118!3944118!24190171     free     free     free       Pediatr+Nephrol 2014 ; 29 (4): 659-64 Nephropedia Template TP {{tp|p=24190171|t=2014. Hnf1beta and nephron segmentation |pdf=|usr=}}{{24190171}} gab.com Text Hnf1beta and nephron segmentation JO: Pediatr Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=24190171 #FOAvip The nephron is the functional unit that executes the homeostatic roles of the kidney in vertebrates. Critical to this function is the physical arrangement of the glomerular blood filter attached to a tubular epithelium that is subdivided into specialized proximal and distal segments. During embryogenesis, nephron progenitors undergo a mesenchymal-epithelial transition (MET) and adopt different segment-specific cell fates along the proximo-distal axis of the nephron. The molecular basis of how these segments arise remains largely unknown. Recent studies using the zebrafish identified the Hnf1beta transcription factor (Hnf1b) as a major regulator of tubular segmentation. In Hnf1b-deficient zebrafish embryos, nephron progenitors fail to adopt the proximo-distal segmentation pattern of the nephron, yet still undergo MET. This observation suggests that the functional segmentation of renal tubular epithelial cells is independent of pathways that induce their epithelialization. Here we review this new role of Hnf1b for nephron segmentation during zebrafish and mouse kidney development. Twit Text FOAVip Hnf1beta and nephron segmentation ????Pediatr Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=24190171 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24190171 #FOAvip English Wikipedia <ref>{{Cite pmid|24190171}}</ref> Hnf1beta and nephron segmentation #MMPMID24190171 Naylor RW; Davidson AJ Pediatr Nephrol 2014[Apr]; 29 (4): 659-64 PMID24190171show ga The nephron is the functional unit that executes the homeostatic roles of the kidney in vertebrates. Critical to this function is the physical arrangement of the glomerular blood filter attached to a tubular epithelium that is subdivided into specialized proximal and distal segments. During embryogenesis, nephron progenitors undergo a mesenchymal-epithelial transition (MET) and adopt different segment-specific cell fates along the proximo-distal axis of the nephron. The molecular basis of how these segments arise remains largely unknown. Recent studies using the zebrafish identified the Hnf1beta transcription factor (Hnf1b) as a major regulator of tubular segmentation. In Hnf1b-deficient zebrafish embryos, nephron progenitors fail to adopt the proximo-distal segmentation pattern of the nephron, yet still undergo MET. This observation suggests that the functional segmentation of renal tubular epithelial cells is independent of pathways that induce their epithelialization. Here we review this new role of Hnf1b for nephron segmentation during zebrafish and mouse kidney development. äHnf1beta and nephron segmentation (epmc).pdf DeepDyve Pubget Overpricing