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10.1007/s00467-013-2603-8 http://scihub22266oqcxt.onion/10.1007/s00467-013-2603-8 C3944099!3944099!23996452     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pediatr+Nephrol 2014 ; 29 (4): 589-95 Nephropedia Template TP {{tp|p=23996452|t=2014. Mechanisms of Gene Activation and Repression by Pax Proteins in the Developing Kidney |pdf=|usr=}}{{23996452}} gab.com Text Mechanisms of Gene Activation and Repression by Pax Proteins in the Developing Kidney JO: Pediatr Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=23996452 #FOAvip During embryonic development, DNA binding proteins help to specify and restrict the fates of pluripotent stem cells. In the developing kidney, Pax2 proteins are among the earliest markers for the renal epithelial cell lineage, with expression in the mesenchyme and in proliferating epithelia. The Pax2 protein is essential for interpreting inductive signals emanating from the ureter bud such that kidney mesenchyme can convert to epithelia. The biochemistry of Pax protein function is being studied in a variety of model systems. Through interactions with the adaptor PTIP, Pax proteins can recruit members of the Trithorax family of histone methyltransferases to imprint activating epigenetic marks on chromatin. However, the interactions with the co-repressor protein Grg4 can inhibit activation and instead recruit Polycomb repressor complexes to promote target gene silencing. We present a model whereby the regulated interactions of Pax proteins with available co-factors mediated activation or gene silencing at different stages of development. The implications for establishing and maintaining the epigenome are discussed. Twit Text FOAVip Mechanisms of Gene Activation and Repression by Pax Proteins in the Developing Kidney ????Pediatr Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=23996452 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23996452 #FOAvip English Wikipedia <ref>{{Cite pmid|23996452}}</ref> Mechanisms of Gene Activation and Repression by Pax Proteins in the Developing Kidney #MMPMID23996452 Patel SR; Ranghini E; Dressler GR Pediatr Nephrol 2014[Apr]; 29 (4): 589-95 PMID23996452show ga During embryonic development, DNA binding proteins help to specify and restrict the fates of pluripotent stem cells. In the developing kidney, Pax2 proteins are among the earliest markers for the renal epithelial cell lineage, with expression in the mesenchyme and in proliferating epithelia. The Pax2 protein is essential for interpreting inductive signals emanating from the ureter bud such that kidney mesenchyme can convert to epithelia. The biochemistry of Pax protein function is being studied in a variety of model systems. Through interactions with the adaptor PTIP, Pax proteins can recruit members of the Trithorax family of histone methyltransferases to imprint activating epigenetic marks on chromatin. However, the interactions with the co-repressor protein Grg4 can inhibit activation and instead recruit Polycomb repressor complexes to promote target gene silencing. We present a model whereby the regulated interactions of Pax proteins with available co-factors mediated activation or gene silencing at different stages of development. The implications for establishing and maintaining the epigenome are discussed. äMechanisms of Gene Activation and Repression by Pax Proteins in the De(epmc).pdf DeepDyve Pubget Overpricing