Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.bbamem.2013.09.004 http://scihub22266oqcxt.onion/10.1016/j.bbamem.2013.09.004 C3943691!3943691!24055819     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24055819&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochim+Biophys+Acta+Biomembr 2014 ; 1838 (4): 1058-67 Nephropedia Template TP {{tp|p=24055819|t=2014. The minimalist architectures of viroporins and their therapeutic implications? |pdf=|usr=}}{{24055819}} gab.com Text The minimalist architectures of viroporins and their therapeutic implications JO: Biochim Biophys Acta Biomembr http://www.kidney.de/pget.php?&tw=1&pmid=24055819 #FOAvip Many viral genomes encode small, integral membrane proteins that form homo-oligomeric channels in membrane, and they transport protons, cations, and other molecules across the membrane barrier to aid various steps of viral entry and maturation. These viral proteins, collectively named viroporins, are crucial for viral pathogenicity. In the past five years, structures obtained by nuclear magnetic resonance (NMR), X-ray crystallography, and electron microscopy (EM) showed that viroporins often adopt minimalist architectures to achieve their functions. A number of small molecules have been identified to interfere with their channel activities and thereby inhibit viral infection, making viroporins potential drug targets for therapeutic intervention. The known architectures and inhibition mechanisms of viroporins differ significantly from each other, but some common principles are shared between them. This review article summarizes the recent developments in the structural investigation of viroporins and their inhibition by antiviral compounds. This article is part of a Special Issue entitled: Viral Membrane Proteins?Channels for Cellular Networking. Twit Text FOAVip The minimalist architectures of viroporins and their therapeutic implications ????Biochim Biophys Acta Biomembr http://www.kidney.de/pget.php?&tw=1&pmid=24055819 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24055819 #FOAvip English Wikipedia <ref>{{Cite pmid|24055819}}</ref> The minimalist architectures of viroporins and their therapeutic implications? #MMPMID24055819 OuYang B; Chou JJ Biochim Biophys Acta Biomembr 2014[Apr]; 1838 (4): 1058-67 PMID24055819show ga Many viral genomes encode small, integral membrane proteins that form homo-oligomeric channels in membrane, and they transport protons, cations, and other molecules across the membrane barrier to aid various steps of viral entry and maturation. These viral proteins, collectively named viroporins, are crucial for viral pathogenicity. In the past five years, structures obtained by nuclear magnetic resonance (NMR), X-ray crystallography, and electron microscopy (EM) showed that viroporins often adopt minimalist architectures to achieve their functions. A number of small molecules have been identified to interfere with their channel activities and thereby inhibit viral infection, making viroporins potential drug targets for therapeutic intervention. The known architectures and inhibition mechanisms of viroporins differ significantly from each other, but some common principles are shared between them. This review article summarizes the recent developments in the structural investigation of viroporins and their inhibition by antiviral compounds. This article is part of a Special Issue entitled: Viral Membrane Proteins?Channels for Cellular Networking. äThe minimalist architectures of viroporins and their therapeutic impli(epmc).pdf DeepDyve Pubget Overpricing